Results 81 to 90 of about 520,175 (264)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Backward Compatibility to Sustain Market Dominance – Evidence from the US Handheld Video Game Industry [PDF]

open access: yes
The introduction of a new product generation forces incumbents in network industries to rebuild their installed base to maintain an advantage over potential entrants.
Kretschmer, Tobias   +2 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

High-Frequency Analysis of Intercalated Multilayer Graphene (IMLG) and Implication for Tunable Terahertz Resonator Design

open access: yesIEEE Access, 2017
Hexagonal boron nitride intercalated multilayer grapheme (hBN-IMLG) promises one of the potential materials for high performance tunable passive components in terahertz (THz) band, due to its good electrical properties and impressive tunability with ...
Xiang Li, Lin-Sheng Wu, Jun-Fa Mao
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Framing for incentive compatibility in choice modelling [PDF]

open access: yes
The incentives that motivate respondents to reveal their preferences truthfully have been a long-standing area of research in the non-market valuation literature.
Mazur, Kasia, Bennett, Jeffrey W.
core  

Table_1_Overcoming Cabbage Crossing Incompatibility by the Development and Application of Self-Compatibility-QTL- Specific Markers and Genome-Wide Background Analysis.XLS

open access: yes, 2019
Cabbage hybrids, which clearly present heterosis vigor, are widely used in agricultural production. We compared two S5 haplotype (Class II) cabbage inbred-lines 87–534 and 94–182: the former is highly SC while the latter is highly SI; sequence analysis ...
Yang Hu (315392)   +11 more
core   +1 more source

Directional stimulus-response compatibility: a test of three alternative principles [PDF]

open access: yes, 1998
The basis of directional stimulus-response compatibility was studied using a task in which 128 participants moved a cursor into targets with a joystick, resembling the operation of certain industrial and construction equipment.
Worringham, Charles J.   +1 more
core   +1 more source

Direct observations of X-rays produced by upward positive lightning

open access: yesScientific Reports
X-rays have been observed in natural downward cloud-to-ground lightning for over 20 years and in rocket-triggered lightning for slightly less. In both cases, this energetic radiation has been detected during the stepped and dart leader phases of downward
Toma Oregel-Chaumont   +5 more
doaj   +1 more source

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