Results 61 to 70 of about 1,516,946 (302)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Common fixed points of R-weakly commuting maps in generalized metric spaces

Fixed Point Theory and Applications, 2011
In this paper, using the setting of a generalized metric space, a unique common fixed point of four R-weakly commuting maps satisfying a generalized contractive condition is obtained. We also present example in support of our result.
Khan Safeer, Abbas Mujahid, Nazir Talat
doaj  

Common fixed points of biased maps of type (A) and applications

International Journal of Mathematics and Mathematical Sciences, 1998
A generalization of compatible maps of type (A) called “biased maps of type (A)” is introduced and used to prove fixed point theorems for certain contractions of four maps.
H. K. Pathak, Y. J. Cho, S. M. Kang
doaj   +1 more source

Fiches pédagogiques de MAPS 8

, 2015
Les MAPSIENS ayant travaillé tout l'été... les fiches pédagogiques des modèles développés lors de MAPS 8 sont peu à peu mis en ligne! retrouvez-les sur les pages de la production pédagogique de MAPS 8 à MAPS..
Réseau MAPS
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Guess who's MAPS?

, 2013
Vous voulez vérifier que vous êtes bien comptabilisé parmi les MAPSiennes et les MAPSiens? Vous voulez savoir qui sont les membres de MAPS? Vous pouvez retrouver tous les noms des personnes qui ont participés à un évènement MAPS sur la page Who is MAPS?
Réseau MAPS
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Common Fixed Points of Generalized Contractive Hybrid Pairs in Symmetric Spaces

Fixed Point Theory and Applications, 2009
Several fixed point theorems for hybrid pairs of single-valued and multivalued occasionally weakly compatible maps satisfying generalized contractive conditions are established in a symmetric space.
Abdul Rahim Khan, Mujahid Abbas
doaj   +2 more sources

Coincidence Points and Common Fixed Points of Cyclic Maps by Implicit Contractive Conditions

مجلة بغداد للعلوم
The study of common fixed points and coincidence points has occupied a large part of the priorities of researchers, especially in the metric space and its generalizations.
Abbas Karim Nahi, Salwa Salman Abed
doaj   +1 more source