Results 71 to 80 of about 597,655 (285)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Preliminary findings from geological mapping of the Hokusai (H5) quadrangle of Mercury [PDF]

, 2016
Quadrangle geological maps from Mariner 10 data cover 45% of the surface of Mercury at 1:5M scale. Orbital MESSENGER data, which cover the entire planetary surface, can now be used to produce finer scale geological maps, including regions unseen by ...
Balme, M. R., Conway, S. J., Rothery, D. A., Wright, J.   +3 more
core  

The Kolmogorov-Smirnov test for the CMB

, 2011
We investigate the statistics of the cosmic microwave background using the Kolmogorov-Smirnov test. We show that, when we correctly de-correlate the data, the partition function of the Kolmogorov stochasticity parameter is compatible with the Kolmogorov ...
A.N. Kolmogorov, D. Fixsen, D. Larson ., J. Michaud, J.C. Mather, Jérôme Michaud, K. Gorski ., M. Doran, Mona Frommert, R. Durrer, Ruth Durrer, S.K. Naess, U. Sawangwit, V. Arnold, WMAP collaboration   +14 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Common Fixed Points of Generalized Contractive Hybrid Pairs in Symmetric Spaces

Fixed Point Theory and Applications, 2009
Several fixed point theorems for hybrid pairs of single-valued and multivalued occasionally weakly compatible maps satisfying generalized contractive conditions are established in a symmetric space.
Abdul Rahim Khan, Mujahid Abbas
doaj   +2 more sources

Common fixed point theorem for noncompatible maps in probabilistic metric space [PDF]

Surveys in Mathematics and its Applications, 2013
In this paper, we prove a common fixed point theorem for noncompatible maps in probabilistic metric space using implicit relation. Our result does not require either the completeness of the space or continuity of the maps.
Suneel Kumar, Sunny Chauhan, B. D. Pant
doaj  

Homotopy Normal Maps

, 2015
Normal maps between discrete groups $N\rightarrow G$ were characterized [FS] as those which induce a compatible topological group structure on the homotopy quotient $EN\times_N G$. Here we deal with topological group (or loop) maps $N\rightarrow G$ being
Bousfield, Brown, Farjoun, Gottlieb, Kan, Matan Prezma, May, Milnor, Nomura, Stasheff   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Common fixed points of R-weakly commuting maps in generalized metric spaces

Fixed Point Theory and Applications, 2011
In this paper, using the setting of a generalized metric space, a unique common fixed point of four R-weakly commuting maps satisfying a generalized contractive condition is obtained. We also present example in support of our result.
Khan Safeer, Abbas Mujahid, Nazir Talat
doaj