Results 61 to 70 of about 437,504 (219)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Simultaneous sEMG Classification of Hand/Wrist Gestures and Forces

Frontiers in Neurorobotics, 2019
Surface electromyography (sEMG) signals represent a promising approach for decoding the motor intention of amputees to control a multifunctional prosthetic hand in a non-invasive way.
Francesca Leone, Cosimo Gentile, Anna Lisa Ciancio, Emanuele Gruppioni, Angelo Davalli, Rinaldo Sacchetti, Eugenio Guglielmelli, Loredana Zollo   +7 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source

“It's something you can't wash off; you carry it with you”: a qualitative study into teachers' experiences of vicarious trauma symptoms during the COVID-19 pandemic in Victoria, Australia

Frontiers in Education
BackgroundThe COVID-19 pandemic caused unprecedented disruption to education systems worldwide, and exacerbated existing challenges in the teaching profession.
Olivia Crivari, Sarah Oxford, Sarah Oxford, Carmen Schroder, Sarah Anderson, Sarah Anderson, Janine McMillan, Janine McMillan   +7 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Whole-body vibration exposure and chronic low back pain among heavy machine operators and long-haul truck drivers in Tanzania: a cross-sectional study

Frontiers in Public Health
BackgroundThe Workers Compensation Fund (WCF) in Tanzania has noted an increased rate of injury claims for work-related musculoskeletal disorders (WRMSDs), particularly chronic low back pain among truck drivers and heavy machine operators.
Israel Nyarubeli, Israel Nyarubeli, Gloria Sakwari, Suleiman Chombo, Susan Reuben, Naanjela Msangi, Robert Duguza, Bryan Francis, Simon Lwaho, Abdulsalaam Omar, John Mduma   +10 more
doaj   +1 more source

A global survey on occupational health services in selected international commission on occupational health (ICOH) member countries

BMC Public Health, 2017
Background The United Nations General Assembly (UNGA), the International Labour Organization (ILO), the World Health Organization (WHO), the International Commission on Occupational Health (ICOH), and the European Union (EU) have encouraged countries to ...
Jorma Rantanen, Suvi Lehtinen, Antonio Valenti, Sergio Iavicoli   +3 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Precarious employment and occupational injuries in the digital age ‒ where should we go from here?

Scandinavian Journal of Work, Environment & Health, 2018
There is growing demand for a clearer understanding of whether precarious work is a social determinant of health (1‒5) and whether non-standard workers with less job security are more vulnerable to adverse safety and health outcomes.
Helen Marucci-Wellman
doaj   +1 more source