Results 81 to 90 of about 2,170,903 (309)

Pay-performance Sensitivity and Firm Size: Insights From the Mutual Fund Industry [PDF]

open access: yes, 2010
I examine the ex ante decision to make an agent\u27s pay-performance sensitivity an inverse function of organization size. I focus on mutual funds and their decision to use compensation contracts that reduce the advisor\u27s marginal compensation as the ...
Cashman, George D.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Investigation of the rise of compensation of high perveance ion beams using a time-resolving ion energy spectrometer [PDF]

open access: yes, 2005
The knowledge of the build up time of space charge compensation (SCC) and the investigation of the compensation process is of main interest for low energy beam transport of pulsed high perveance ion beams under space charge compensated conditions.
Jakob, Ansgar   +4 more
core  

Partial dosage compensation in Strepsiptera, a sister group of beetles. [PDF]

open access: yes, 2015
Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Bachtrog, Doris, Mahajan, Shivani
core   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Associate Professor Turnover at America’s Public and Private Institutions of Higher Education [PDF]

open access: yes, 2004
This paper uses data from the American Association of University Professors annual salary survey to compute continuation rates for associate professors at American colleges and universities during the 1996-97 to 2001-2002 period.
Nagowski, Matthew P
core   +1 more source

Landholders’ Involvement in the Compulsory Acquisition of Land and Compensation Process in Bauchi, Nigeria [PDF]

open access: yes, 2019
This study aims to assess landholder’s involvement in the compulsory acquisition of land on their satisfaction with the compensation process in Bauchi, Nigeria, to identify areas of weakness in the process and propose areas of improvement.
Adekunle, Muhammad Usman   +4 more
core   +2 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela   +13 more
wiley   +1 more source

Pensions in the laboratory: the role of commitment and reputation for deferred compensation in multi-period labor contracts [PDF]

open access: yes, 2009
This paper examines the relationship between firms‘ wage offers and workers‘ supply of effort in a multi-period environment. If firms are able to commit to a schedule of wage payments, in equilibrium they will offer deferred compensation: first-period ...
Huck, S., Seltzer, A.J., Wallace, B.
core  

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