Results 71 to 80 of about 416,311 (267)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Simultaneous sEMG Classification of Hand/Wrist Gestures and Forces

Frontiers in Neurorobotics, 2019
Surface electromyography (sEMG) signals represent a promising approach for decoding the motor intention of amputees to control a multifunctional prosthetic hand in a non-invasive way.
Francesca Leone, Cosimo Gentile, Anna Lisa Ciancio, Emanuele Gruppioni, Angelo Davalli, Rinaldo Sacchetti, Eugenio Guglielmelli, Loredana Zollo   +7 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

“It's something you can't wash off; you carry it with you”: a qualitative study into teachers' experiences of vicarious trauma symptoms during the COVID-19 pandemic in Victoria, Australia

Frontiers in Education
BackgroundThe COVID-19 pandemic caused unprecedented disruption to education systems worldwide, and exacerbated existing challenges in the teaching profession.
Olivia Crivari, Sarah Oxford, Sarah Oxford, Carmen Schroder, Sarah Anderson, Sarah Anderson, Janine McMillan, Janine McMillan   +7 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Compensation conundrum

Perspectives in Clinical Research, 2012
Pressured by questions tabled in parliament that point to a lack of adequate enforcement of regulations, the DCG(I) has abruptly initiated action to ensure payment of compensation for trial-related injuries. While it is astounding that non-compliance to the existing regulations could have gone unnoticed by quality assurance staff as well as by the ...
openaire   +3 more sources

Whole-body vibration exposure and chronic low back pain among heavy machine operators and long-haul truck drivers in Tanzania: a cross-sectional study

Frontiers in Public Health
BackgroundThe Workers Compensation Fund (WCF) in Tanzania has noted an increased rate of injury claims for work-related musculoskeletal disorders (WRMSDs), particularly chronic low back pain among truck drivers and heavy machine operators.
Israel Nyarubeli, Israel Nyarubeli, Gloria Sakwari, Suleiman Chombo, Susan Reuben, Naanjela Msangi, Robert Duguza, Bryan Francis, Simon Lwaho, Abdulsalaam Omar, John Mduma   +10 more
doaj   +1 more source

A global survey on occupational health services in selected international commission on occupational health (ICOH) member countries

BMC Public Health, 2017
Background The United Nations General Assembly (UNGA), the International Labour Organization (ILO), the World Health Organization (WHO), the International Commission on Occupational Health (ICOH), and the European Union (EU) have encouraged countries to ...
Jorma Rantanen, Suvi Lehtinen, Antonio Valenti, Sergio Iavicoli   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source