Results 211 to 220 of about 151,430 (244)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Governance and Update Process for Lifestyle Medicine Core Competencies and Definitions. [PDF]

Am J Lifestyle Med
Rea BL, Cheema S, Lanza S, Makinde MT, Matthews S, Palma M, Kadosh MA, Lapsa-Lešinske A, Karlsen MC.   +8 more
europepmc   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

A Chinese Expert Consensus on the Artificial Intelligence Proficiency of Medical Students: Competencies and the Multi-Modal Assessment. [PDF]

Health Care Sci
Gong M, Li J, Ma Y, Jin B, Chen W, Hou Y, Hong L, Lai T, Zhang B, Wu G, Zeng Z.   +10 more
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

<i>AIM</i> (Analyze-Interpret-Manage): A Novel NAPLEX-Aligned Analytical Assessment Framework for Measuring Individual and Team Critical Thinking Using Generative AI. [PDF]

Pharmacy (Basel)
Malhotra A.
europepmc   +1 more source

Sostenibilitat, Tecnologia i Excel·lència. Programa STEP [PDF]

, 2010
Busquets Rubio, Pere
core  

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

To the Editor: Trauma-Informed Care Competencies and Orthopedic Training. [PDF]

J Grad Med Educ
Ahmad M, Al-Marrawi Y.
europepmc   +1 more source

Desenvolupament de les competències transversals d’intervenció: disseny del seminari de 4t curs de psicologia [PDF]

, 2011
Bruna, Olga, Cabré, Víctor, Cano, Maribel, Chaves, Antonio, Corbella, Sergi, Farriols, Núria, Fernández, Victòria, Pacheco Pérez, Meritxell, Ros, Eulàlia, Vilaregut, Anna   +9 more
core