Results 171 to 180 of about 2,577,512 (424)

Constant Enzymatic in situ Production of H2O2 for an Unspecific Peroxygenase by an l–Amino Acid Oxidase

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Abstract Unspecific Peroxygenases have been the subject of a lot of research in the recent past as they offer opportunities for green hydroxylation reactions using hydrogen peroxide (H2O2) as donor. A striking problem of UPOs is their low stability against their own co‐substrate H2O2. In order to prevent the deactivation, we developed an enzyme cascade
Simon Last   +6 more
wiley   +1 more source

Dearomative, Intramolecular Bromoetherification of Carbohydrate‐derived Glycosyl Furans: Access to Enantiopure 6‐Bromo‐Furo[3,2‐b]furans

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Abstract Glycosyl furans represent versatile chiral platform molecules that can be readily accessed via the Garcia Gonzalez reaction. Herein, we report a dearomative, intramolecular bromoetherification of carbohydrate‐derived glycosyl furans to generate enantiopure 6‐bromo‐furo[3,2‐b]furans in up to 69% yield. The method employs N‐Br aromatic amides as
William J. Berkey   +5 more
wiley   +1 more source

Ammonia Dynamics in the Human Body: Insights in Biomedical Sensing Technologies

open access: yesAdvanced Sensor Research, EarlyView.
Ammonia (NH3) is a significant biomarker in diagnostics, affecting the respiratory system, stomach, liver, kidneys, bladder, and gastrointestinal tract. NH3 detection, using sensors, has the potential to improve medical diagnosis. This review examines recent advancements in NH3 sensing technologies and explores future research directions, including ...
Annelot Nijkoops   +8 more
wiley   +1 more source

CRISP-NAM: Competing Risks Interpretable Survival Prediction with Neural Additive Models [PDF]

open access: yesarXiv
Competing risks are crucial considerations in survival modelling, particularly in healthcare domains where patients may experience multiple distinct event types. We propose CRISP-NAM (Competing Risks Interpretable Survival Prediction with Neural Additive Models), an interpretable neural additive model for competing risks survival analysis which extends
arxiv  

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

open access: yesAdvanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang   +14 more
wiley   +1 more source

Transport of Non-Steroidal Anti-Inflammatory Drugs across an Oral Mucosa Epithelium In Vitro Model

open access: yesPharmaceutics
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most prescribed drugs to treat pain or fever. However, oral administration of NSAIDs is frequently associated with adverse effects due to their inhibitory effect on the constitutively ...
Grace C. Lin   +4 more
doaj   +1 more source

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