Results 221 to 230 of about 2,577,512 (424)

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Nursing education in the digital era: the role of digital competence in enhancing academic motivation and lifelong learning among nursing students. [PDF]

BMC Nurs
Amin SM, El-Fattah Mahgoub SA, Tawfik AF, Khalil DE, El-Sayed AAI, Atta MHR, Albzia A, Morsy Mohamed SR.   +7 more
europepmc   +1 more source

Characterisation of red fluorescent protein FLIM properties and comparison with novel StayGold live cell imaging [PDF]

BIO Web of Conferences
Tripal Philipp, Said Hanan, Schmid Benjamin, Palmisano Ralph   +3 more
doaj   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Relationship Between Empathy, Moral Sensitivity, and Spiritual Care Competence Among Nurses: A Cross-Sectional Study. [PDF]

J Nurs Manag
Li Y, Wen X, Su Y, Zeng X.
europepmc   +1 more source

Effect of pH on competence development and deoxyribonucleic acid uptake in Streptococcus sanguis (Wicky) [PDF]

, 1976
Jon M. Ranhand
openalex   +1 more source

AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents

Advanced Science, EarlyView.
An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang, Li Zhang, Shoudong Wang, Xin Wang, Suning Li, Pingping Gong, Mengyan Bai, Arnav Paul, Nathan Tvedt, Hengrui Ren, Maoxiang Yang, Zhihui Zhang, Shaodong Zhou, Jiayi Sun, Xianjin Wu, Huaqin Kuang, Zhenghua Du, Yonghui Dong, Xiaolei Shi, Meina Li, Diwakar Shukla, Long Yan, Yuefeng Guan   +22 more
wiley   +1 more source

Self-efficacy as a mediator in the relationship between clinical learning environment and core nursing competence of intern nursing students: a multicentre cross-sectional study. [PDF]

BMJ Open
Pu Y, Xie H, Fu L, Zhang X, Long T, Su X, Feng X, Feng X.   +7 more
europepmc   +1 more source

Reinforcing Stromal Cell Spheroid Through Red‐Light Preconditioning for Advanced Vascularization

Advanced Science, EarlyView.
This study presents a novel approach to enhance stromal cell therapy for myocardial infarction by combining OLED‐based photobiomodulation (OPBM) preconditioning with 3D spheroid culture of hADSCs. The engineered spheroids improve angiogenesis, arterialization, and cardiac function in vivo, offering a next‐generation therapeutic strategy to overcome ...
Yu‐Jin Kim, Hyeok Kim, Dong‐Hyun Lee, Yeong Hwan Kim, Jae‐Hyun Park, Woo‐Sup Sim, Jin‐Ju Kim, Kiwon Ban, Soong Ho Um, Hyun Ji Park, Michael E. Davis, Hun‐Jun Park, Suk Ho Bhang   +12 more
wiley   +1 more source

Assessing educational needs of nurses' ethical competence based on the four components model of moral behaviour: a cross-sectional study using the Borich needs assessment and locus for focus models. [PDF]

BMC Nurs
Ha K, Oh Y.
europepmc   +1 more source