Results 231 to 240 of about 11,455,528 (298)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Research on the effect of evidence-based practice based on core competencies on improving breastfeeding counseling skills of obstetric nurses. [PDF]

Front Pediatr
Ma Y, Li Y, Lu X.
europepmc   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Latent profiles of death coping competence among nursing interns and associations with death attitudes, death exposure, and death education; a cross-sectional survey. [PDF]

Int J Nurs Stud Adv
Xi X, Le J, Zeng T, Zhou C, Liao J, Wang Y, Mao J.   +6 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Maternal Depressive Symptoms, Positive Family Expressions, and Child Peer Competence Across the Elementary School Years. [PDF]

Fam Process
Wu Q, Zhang XK, MacVicar F, Lee CR, Jalapa K.   +4 more
europepmc   +1 more source

Pharmacology educators as leaders of programmatic assessment for safe prescribing in competency-based medical education. [PDF]

Front Pharmacol
Zagaar M, Karpa K, Szarek JL, Koenig J, Cormier L, Mifsud J, Venderova K, Restini C.   +7 more
europepmc   +1 more source

Analysis of Quality Normative Requirements: Contributions to the Alignment and Standardization of Standards Applied in Health Laboratories. [PDF]

BioTech (Basel)
Fernandez SLC, Hodel KVS, Souza RA, Malta-Santos H, Ribeiro CDF, Machado BAS.   +5 more
europepmc   +1 more source

Effect of the Jeffries Simulation Framework on the Core Competence of New Graduate Paediatric Surgery Nurses: A Quasi-Experimental Study. [PDF]

Nurs Open
Luo W, Yang R, Feng L, Liang Y.
europepmc   +1 more source

Response to Letter to the Editor for AO Spine Clinical Practice Recommendations for the Management of Spinal Tuberculosis. [PDF]

Global Spine J
Scherer J.
europepmc   +1 more source