Results 81 to 90 of about 1,579,148 (310)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
A model of Firm's Growth in a knowledge based economy [PDF]
, 2015 Knowledge-based economies use knowledge as an input of production to produce knowledge-intensive products and services. In such economies, a firm’s growth crucially depends on knowledge accumulation, technical change and the resulting innovation ...
Seddighi, Hamid
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FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Using ICT to promote teachers’ competences: strategies and challenges
EAI Endorsed Transactions on e-Learning, 2015 When merged with new pedagogical practices the use of open social web tools as a means to mediate and support teacher training triggers a whole new set of implications for education and individuals.
Margarida Lucas, António Moreira
doaj +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Parallel Distributed Grammar Engineering for Practical Applications [PDF]
, 2011 Based on a detailed case study of parallel grammar development distributed across two sites, we review some of the requirements for regression testing in grammar engineering, summarize our approach to systematic competence and performance profiling, and ...
Bender, Emily M. +4 more
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Kompetence za poucevanje za trajnostni razvoj na podrocju izobrazevanja uciteljev [PDF]
, 2013 Competences are intensively discussed in the context of cross-curricular themes, such as Sustainable Development and Education for Sustainable Development (ESD), especially in light of the United Nations Decade for ESD (2004–2015).
Rauch, Franz, Steiner, Regina
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Reforming Juvenile Justice Systems: Beyond Treatment [PDF]
, 2010 Evaluates the role of youth development and cultural competence in the Reclaiming Futures initiative to improve substance abuse interventions as part of juvenile justice reform.
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