Results 121 to 130 of about 1,185,920 (393)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Occupational dimension of the INFODORADCA+ project [PDF]

open access: yesEdukacja Ustawiczna Dorosłych, 2019
Knowledge about occupations – professionalization, is a basic element of work pedagogy. It allows for professional observation of the process of professional tasks implementation, and then for assigning to each distinguished task a set of ...
Stefan Kwiatkowski
doaj  

THE INTELLECTUAL CAPITAL OF AN ORGANIZATION AS AN ECONOMIC RESOURCE FOR INNOVATION BUSINESS

open access: yesВестник Северо-Кавказского федерального университета, 2022
The paper discusses the role of intellectual capital and competences in arising and enhancement of contemporary innovation business. It stresses the crucial impact of knowledge management system on ascendance of organizations’ competitiveness.
Robert M. Nizhegorodtsev   +2 more
doaj  

Experience in teaching the course “Theory and Methodology of Education”at the Rivne State Humanitarian University (Ukraine): good practices and challenges [PDF]

open access: yesStudia z Teorii Wychowania
Reforming the system of higher education in Ukraine has set requirements for changes in approaches, paradigms, content and forms of work with students, including pedagogical specialties. Forced changes in the teaching of future teachers took place during
Iryna Androshchuk, Oksana Petrenko
doaj   +1 more source

Simulation-based model course to demonstrate seafarers' competence for deck officers' discipline [PDF]

open access: yes, 2014
Postprint (published ...
Barahona Fuentes, Claudia   +10 more
core  

Transversal Competences: Their Importance and Learning Processes by Higher Education Students

open access: yesEducation sciences, 2018
At a time when the labour market is blocked and simultaneously rapidly changing, with the emergence of new professional and scientific areas, the higher education mission becomes less indisputable and more indeterminate and challenging.
M. Sá, Sandro Serpa
semanticscholar   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Study of Endocrine-Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE-MILCH PROJECT

open access: yesMolecules
Exposure to endocrine-disrupting chemicals (EDCs) is inevitable, and growing scientific evidence indicates that even very low doses can negatively impact human health, particularly during pregnancy and the neonatal period. As part of the European project
Francesca Nuti   +8 more
doaj   +1 more source

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