Results 241 to 250 of about 427,425 (296)

Development of a core competence model for improving medical college students' ability in respond to public health emergencies. [PDF]

Front Public Health
Liu F, Huang S, Chen F, Yang S, Wu L, Lin Y, He B, Hu Z.   +7 more
europepmc   +1 more source

The EU and its Member States in the World: Legal and Political Debates [PDF]

, 2017
Odermatt, J., Van den Sanden, T.
core  

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

The evolving landscape of airway education in anesthesia for head and neck surgery. [PDF]

Curr Opin Anaesthesiol
Fuchs A, Nekhendzy V, Greif R.
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Psychological Resources, Stress, and Well-Being in Adolescence: An Integrative Structural Model. [PDF]

Children (Basel)
Rózsa S, Kövesdi A.
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Implementing pain competencies in Canadian physiotherapy education: Challenges, barriers, and opportunities. [PDF]

Can J Pain
Augeard N, Longtin C, Bussières A, Bostick G, Thomas A, Miller J, Tousignant-Laflamme Y, Walton D, Hudon A, Cooper L, Singer L, Amari F, Wideman TH.   +12 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Effectiveness of a controlled trial of nutrition education in primary school, ZELIAKIDE project: knowledge and mid-morning snack consumption. [PDF]

BMC Public Health
Vázquez-Polo M, Churruca I, Lasa A, Perez-Junkera G, Larretxi I, Bustamante MÁ, Martinez O, Navarro V.   +7 more
europepmc   +1 more source