Results 71 to 80 of about 36,353 (268)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

ANALYSIS OF CURRENT STATE IN BUSINESS-EDUCATION AND ISSUES REGARDING INTRODUCTION OF COMPETENCE-BASED APPROACH

Вестник Северо-Кавказского федерального университета, 2022
The article reveals an analysis of the current state of things in business-education. There is an explanation for the methodological grounds of imple-menting business-education following the competence-based approach. Competence models are used to define
Viktor A. Fursov, Irina V. Solovieva, Natalya V. Lazareva   +2 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Strategy-based evaluation of a formative simulation test assessing professionally relevant competences of undergraduate medical students

GMS Journal for Medical Education
Objectives: A strategy-based evaluation of new teaching or examination formats is recommended in order to check their suitability before a possible integration into a medical curriculum.
Prediger, Sarah, Gärtner, Julia, Jebram, Lea, Harendza, Sigrid   +3 more
doaj   +1 more source

Human Resources Readiness for Industry 4.0

Journal of Open Innovation: Technology, Market and Complexity, 2019
Industry 4.0 is related to major changes, particularly in production. As such changes might have major implications for the labour market; the paper focuses on the assumptions of the human capital and its preparedness for Industry 4.0 in the Czech ...
Jaroslav Vrchota, Monika Mařiková, Petr Řehoř, Ladislav Rolínek, Radek Toušek   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Competence and Competence Development [PDF]

, 2012
What are today's main concepts and theories - and the main stakes - associated with the issue of competences in organizations? Several topics are discussed, including competence issues regarding the evolution of work, professionalization, competence evaluation, competence management, and the competences of adult educators and trainers, as well as ...
openaire   +2 more sources

Kompetencja międzykulturowa 
w nauczaniu języka polskiego jako obcego

Postscriptum Polonistyczne, 2020
In the article the following terms have been revised: competences, communicative competence, intercultural competence. The classification of some new competences required in glottodidactics has been suggested.
Urszula Żydek-Bednarczuk
doaj