Results 171 to 180 of about 2,915,090 (307)

Keeping Open Surgery Alive: A Competency-Based Approach to Elevating Resident Skills. [PDF]

Ann Surg Open
Andreatta PB, Franklin B, Koeberle N, Bowyer M, Bradley M.   +4 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Perspectives on competency-based feedback for training non-specialists to deliver psychological interventions: multi-site qualitative study of the EQUIP competency-based approach. [PDF]

BJPsych Open
Elnasseh A, Mehta VS, Manolova G, Pedersen GA, Golden S, Eloul L, Gebrekristos F, Collins PY, Mutavi T, Mbwayo AW, Mathai M, Concepcion T, El Masri R, Steen F, Galea JT, Contreras C, Akellot J, Kasujja R, Wasereka S, Mutamba BB, Tol WA, Raji M, Moufarrej S, Schafer A, Kohrt BA.   +24 more
europepmc   +1 more source

England uses a competency-based approach to consent for health interventions. [PDF]

Eur J Hum Genet, 2017
Harling C.
europepmc   +1 more source

Competence-based approach in education

Science Almanac, 2014
openaire   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Education and training of clinical and translational study investigators and research coordinators: A competency-based approach. [PDF]

J Clin Transl Sci, 2017
Calvin-Naylor NA, Jones CT, Wartak MM, Blackwell K, Davis JM, Divecha R, Ellerbeck EF, Kieburtz K, Koziel MJ, Luzuriaga K, Maddox J, Needler NA, Murphy S, Pemberton K, Radovich C, Rubinstein EP, Selker HP, Tenaerts P, Unsworth K, Wilson K, Wright JE, Barohn R, Shanley TP.   +22 more
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Overview of quality standards for competency-based addiction training and education programs in postgraduate and continuing medical studies: a Systematic Review.

BACKGROUND: Medical profession plays a crucial role in preventing and treating substance use disorders. However, the quality of addiction-focused medical education, considering only postgraduate (GME) and continuing medical education (CME) programs ...
Pokorná, Vendula, Zborník, Tadeáš Samuel, Lososová, Amalie, Nováková, Elizabeth, Svěcená, Kateřina, Volfová, Anna, Miovský, Michal   +6 more
core   +1 more source