Results 51 to 60 of about 134,408 (268)

Competence and competence development [PDF]

, 2012
What are today's main concepts and theories - and the main stakes - associated with the issue of competences in organizations? Several topics are discussed, including competence issues regarding the evolution of work, professionalization, competence evaluation, competence management, and the competences of adult educators and trainers, as well as ...
openaire   +2 more sources

Predictive capability of foundational concepts tests for problem-solving using machine learning concepts: Evaluating project-based learning courses in artificial intelligence literacy education

Computers and Education: Artificial Intelligence
In the artificial intelligence (AI) era, secondary and university students should be able to apply AI for problem-solving. This study designed and evaluated an AI literacy programme to enhance understanding of machine learning concepts.
Siu Cheung Kong, Chunyu Hou
doaj   +1 more source

Trust-based Modelling of Multi-criteria Crowdsourced Data

Data Science and Engineering, 2017
As a recommendation technique based on historical user information, collaborative filtering typically predicts the classification of items using a single criterion for a given user.
Fátima Leal, Benedita Malheiro, Horacio González-Vélez, Juan Carlos Burguillo   +3 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Assessing Priority Competencies for Evaluation Capacity Building in Extension

Journal of Human Sciences and Extension, 2020
Program planning and evaluation activities play a critical role in the quality of Extension programs. The literature consistently identifies program planning and evaluation as core Extension competencies.
Lendel K. Narine, Amanda D. Ali
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Ultrabroadband high-resolution silicon RF-photonic beamformer

Nature Communications
Microwave photonics aims to overcome the limitations of radiofrequency devices and systems by leveraging the unique properties of optics in terms of low loss and power consumption, broadband operation, immunity to interference and tunability.
Pablo Martinez-Carrasco, Tan Huy Ho, David Wessel, José Capmany   +3 more
doaj   +1 more source

Developing and validating an artificial intelligence ethical awareness scale for secondary and university students: Cultivating ethical awareness through problem-solving with artificial intelligence tools

Computers and Education: Artificial Intelligence
Although there is growing attention to artificial intelligence (AI) ethics education with the rapid surge of AI technology, little research has explored the use of problem-solving to cultivate students' AI ethical awareness.
Siu Cheung Kong, Jinyu Zhu
doaj   +1 more source