Results 191 to 200 of about 36,904 (264)

Basic diaphragm ultrasound training: Curriculum implementation and learning trajectory among diaphragm ultrasound naive trainees. [PDF]

World J Methodol
Ng KWP, See KC.
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

AI-Mediated Relational Competence in Medical Education: Construct Rationale and Curriculum Maturity Framework. [PDF]

JMIR Med Educ
McGrath RJ.
europepmc   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Impact of a vertically integrated, symptom-oriented teaching program for hematuria management on clinical competency transfer among urology clerkship students. [PDF]

BMC Med Educ
Peng S, Wei Y, Dai C, Liang Y, Huang L.
europepmc   +1 more source

Domain-Differentiated Generative AI Competency Self-Efficacy Among University EFL Teachers: Patterns and Predictors. [PDF]

Behav Sci (Basel)
Altalib A.
europepmc   +1 more source

The CBHPE Outcomes Theory of Change: An International Consensus Statement on the Mechanisms and Outcomes of Competency-Based Education in the Health Professions. [PDF]

Perspect Med Educ
Chen AMH, Rhoney DH, Goldhamer MEJ, Ekpenyong A, Humphrey-Murto S, Caretta-Weyer H, Snell L, Damodaran A, Englander R, Hall AK, Huwendiek S, Molgaard L, Oswald A, Schumacher DJ, Chou FC, Tanaka P, Frank JR, As members of the International Competency-based Education in the Health Professions Collaborators.   +17 more
europepmc   +1 more source

Research on the Impact of Generative Artificial Intelligence Usage Behavior on the Learning Outcomes of Higher Vocational Students. [PDF]

Behav Sci (Basel)
Song Y, Zhao K, Li L, Dong W.
europepmc   +1 more source