Results 41 to 50 of about 14,665,554 (294)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Designing a Competency Assessment Model for Information Technology Professionals Using the Fuzzy Expert System Approach [PDF]

مدیریت بهره وری, 2020
Possessing appropriate human resources is undoubtedly the most important organizational competitive advantage in today's state of flux governing the world.
Mohammad Taghi Taghavifard, Mohammad Javad Jalili, Mirali Seyednaghavi, Iman Raeesi Vanani   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analyzing student response processes to refine and validate a competency model and competency-based assessment task types

Frontiers in Education
Regarding competency-oriented teaching in higher education, lecturers face the challenge of employing aligned task material to develop the intended competencies.
Chantal Soyka, Niclas Schaper
doaj   +1 more source

Redesign the model of selection and appointment of managers of the social security organization based on competency models with a data-based approach

مجله علوم روانشناختی, 2022
Background: The Social Security Organization, as the largest insurance and treatment institution in the country, has a great responsibility to the members of the society.
khalil khomideh, hasan rangriz, hamzeh khastar, mehdi Kheirandish   +3 more
doaj  

The Perceived Applicability of Coaching Skills among Human Resource Business Partners of South African State-Owned Entities

Journal of Management and Entrepreneurship Research, 2022
Objective: HRBPs working in the State-owned entity (SOE) industry face a few challenges that inhibit them from being true partners to senior management teams.
Thato Mmaditla, Elona N. Ndlovu-Hlatshwayo   +1 more
doaj   +1 more source

Modeling Human Morphological Competence [PDF]

Frontiers in Psychology, 2020
One of the central debates in the cognitive science of language has revolved around the nature of human linguistic competence. Whether syntactic competence should be characterized by abstract hierarchical structures or reduced to surface linear strings has been actively debated, but the nature of morphological competence has been insufficiently ...
Yohei Oseki, Yohei Oseki, Alec Marantz, Alec Marantz, Alec Marantz   +4 more
openaire   +3 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

A Systematic Review of Evidence-based General Competency Models: Development of a General Competencies Taxonomy

Journal of Work and Organizational Psychology
The purpose of this research was to develop a taxonomy of competencies common across different jobs, occupations, and organizations. To achieve this objective, a definition of competency was constructed and a systematic literature review was conducted ...
David Arribas-Aguila, Gloria Castaño, Rosario Martínez-Arias   +2 more
doaj   +1 more source