Results 61 to 70 of about 14,665,554 (294)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Transforming a competency model to assessment items

open access: yes, 2007
The problem of comparing and matching different learners’ knowledge arises when assessment systems use a one-dimensional numerical value to represent “knowledge level”.
Gilbert, Lester   +2 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Designing the educational system for the management levels of Parsian Bank Branches (senior executives, senior executives) Competency-Based [PDF]

open access: yesپژوهش در نظام‌های آموزشی, 2021
The purpose of this study was to design a training system for levels of management of Parsian Bank Branches based on merit. The methodology of this research is descriptive-correlational and of applied type in which the combination (quantitative ...
mehrnaz afshar   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Designing a Competency Model to select the senior managers in the Ministry of Education: Qualitative Approach [PDF]

open access: yesپژوهش در نظام‌های آموزشی, 2021
Present study aimed to identify the main components of competency of senior managers in the Ministry of Education to introduce a desirable competency model at the request of Ministry of Education of Iran. This study is applied research due to the purpose,
Mahdie Setayeshmehr   +2 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Competency Pool and the competency model for cyber and information security professionals

open access: yes, 2021
The extracted competencies of the competency model analysis and the competency model for cyber and information security professionals are ...
Bendler, Daniel
core   +1 more source

Towards a competency model for adaptive assessment to support lifelong learning

open access: yes, 2007
Adaptive assessment provides efficient and personalised routes to establishing the proficiencies of learners. We can envisage a future in which learners are able to maintain and expose their competency profile to multiple services, throughout their life,
Gilbert, Lester   +2 more
core   +1 more source

Designing a Competency Model for Senior Managers of Gas Refineries in South Pars Gas Complex (S.P.G.C.) [PDF]

open access: yesفرایند مدیریت و توسعه, 2021
This study is conducted aiming to design a competency model for senior managers of South Pars Gas Refineries. The approach of the research was qualitative.
Ehsan Davoodi   +3 more
doaj  

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