DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Transforming a competency model to assessment items
The problem of comparing and matching different learners’ knowledge arises when assessment systems use a one-dimensional numerical value to represent “knowledge level”.
Gilbert, Lester +2 more
core +1 more source
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Designing the educational system for the management levels of Parsian Bank Branches (senior executives, senior executives) Competency-Based [PDF]
The purpose of this study was to design a training system for levels of management of Parsian Bank Branches based on merit. The methodology of this research is descriptive-correlational and of applied type in which the combination (quantitative ...
mehrnaz afshar +2 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Designing a Competency Model to select the senior managers in the Ministry of Education: Qualitative Approach [PDF]
Present study aimed to identify the main components of competency of senior managers in the Ministry of Education to introduce a desirable competency model at the request of Ministry of Education of Iran. This study is applied research due to the purpose,
Mahdie Setayeshmehr +2 more
doaj
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Competency Pool and the competency model for cyber and information security professionals
The extracted competencies of the competency model analysis and the competency model for cyber and information security professionals are ...
Bendler, Daniel
core +1 more source
Towards a competency model for adaptive assessment to support lifelong learning
Adaptive assessment provides efficient and personalised routes to establishing the proficiencies of learners. We can envisage a future in which learners are able to maintain and expose their competency profile to multiple services, throughout their life,
Gilbert, Lester +2 more
core +1 more source
Designing a Competency Model for Senior Managers of Gas Refineries in South Pars Gas Complex (S.P.G.C.) [PDF]
This study is conducted aiming to design a competency model for senior managers of South Pars Gas Refineries. The approach of the research was qualitative.
Ehsan Davoodi +3 more
doaj

