Results 101 to 110 of about 1,617,233 (339)
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
THE ESSENCE OF COMPETITIVENESS, COMPETITIVE ADVANTAGES AND COMPETITIVE STRATEGIES
, 2023 The article discusses the concept of competition, the main features of competition, and types of competition. An analysis was carried out, positive and negative aspects were identified.
openaire +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
“Pay for Delay” – A Subtly Hidden, Overlooked or Ignored Transatlantic Divide: Exemplified on the Actavis decision of the US Supreme Court and the Servier decision of the EU Commission [PDF]
Zbornik Znanstvenih Razprav, 2016 The relationship between antitrust law and intellectual property rights, as exclusive rights, i.e. legal monopolies, has always been characterized by a mutual distrust of protagonists of either discipline.
Joseph Straus
doaj
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
An empirical analysis of debit card interchange fee regulation: Evidence from Brazil
Latin American Journal of Central Banking, 2023 This paper presents an empirical analysis of the introduction, in October 2018, of maximum thresholds (“caps”) on debit card interchange fees for domestic payment cards in Brazil.
Daniel Tavares de Castro +2 more
doaj
The Possibility of Competition in Commerce and Industry [PDF]
, 1912 John B. Clark
openalex +1 more source
, 2003 This paper introduces optimal competition: the best form of competition in an industry that a competition authority can achieve under the information constraint that it cannot observe firms' effciency levels.We show that the optimal competition outcome in an industry becomes more competitive as more money is spent in the industry, as the competition ...
openaire +6 more sources