Results 101 to 110 of about 4,025,054 (343)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Can We Protect Competition without Protecting Consumers? [PDF]

, 2010
This paper suggests that an interpretation of competition solely as a means to increase consumer welfare eliminates substantial characteristics from competition as a process, depriving competition from its original meaning.
Andriychuk, Oles
core  

Competition in financial services [PDF]

, 2015
In the financial services sector, the failure of a single institution can have a compounding effect on the sector, and on national and global economies. In particular, there is systemic risk from inter-institution lending, and this effect is more complex
Carolyn M. Evans, Charlotte Penel, Deborah Healey, Marina Nehme, Rob Nicholls   +4 more
core   +1 more source

sprynger: Scriptable bibliometrics using a Python interface to Springer Nature

SoftwareX
We present a wrapper for the Springer Nature RESTful API written for Python 3. The wrapper allows users to access their free-to-use endpoints via user-friendly interfaces and can be used without prior knowledge of RESTful APIs.
Nils A. Herrmann, Michael E. Rose
doaj   +1 more source

Financial innovation and digitalization promote business growth: The interplay of green technology innovation, product market competition and firm performance

, 2023
Jaffar Abbas, Daniel Balsalobre‐Lorente, Khalid Ibrahim Al‐Sulaiti, Ibrahim Al-Sulaiti, Osama Aldereai   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Competition between Competition Rules [PDF]

Open borders imply systems competition. This paper studies the implications of systems competition for the national co mpetition rules. It is shown that an equilibrium where all countries retain their antitrust laws does not exist, since abolishing this ...
Hans-Werner Sinn
core  

Competition fosters trust [PDF]

, 2007
We study the effects of reputation and competition in a stylized market for experience goods. If interaction is anonymous, such markets perform poorly: sellers are not trustworthy, and buyers do not trust sellers.
Huck, S., Luenser, G., Tyran, J.-R.
core  

On Microservice-Based Architecture for Digital Forensics Applications: A Competition Policy Perspective

Future Internet
Digital forensics systems are complex applications consisting of numerous individual components that demand substantial computing resources. By adopting the concept of microservices, forensics applications can be divided into smaller, independently ...
Fragkiskos Ninos, Konstantinos Karalas, Dimitrios Dechouniotis, Michael Polemis   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source