Results 91 to 100 of about 1,253,967 (267)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Scientific ReportsThis study examined the psychometric properties of the Chinese version of the Multidimensional Competitive Orientation Inventory (Ch-MCOI) in adults from Mainland China.
Yuqian Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
ACCC telecommunications report 2014-15 [PDF]
, 2016 A consumer market hungry for data is driving competition and leading to better service offerings for Australians, according to two new reports. Prepared annually by the Australian Competition and Consumer Commission (ACCC), the reports provide a
Australian Competition and Consumer Commission
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Leniency in EU competition law International competition law series ;, 84./ Ingrid Margrethe Halvorsen Barlund. [PDF]
, 2020 Leniency in EU Competition Law' provides a comprehensive analysis of the leniency procedure in the European Union (EU) cartel enforcement. Applications for lenient treatment by whistleblowers are an essential feature of cartel enforcement.
Halvorsen Barlund Ingrid Margrethe
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Optimal substantive standards for competition authorities [PDF]
, 2016 Initial research was funded by an ESRC grant RES-052-23-221I “Optimal Enforcement and Decision Structures for Competition Policy” and subsequently it has been co-financed by the European Union (European Social Fund – ESF) and Greek National funds through
Ulph, David Tregear +2 more
core +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
ACCC sets reasonable terms of access to the line sharing service [PDF]
, 2007 The Australian Competition and Consumer Commission today published a final determination made in the arbitration of a dispute over access to the Line Sharing Service (LSS).
Australian Competition and Consumer Commission
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