Results 71 to 80 of about 1,250,387 (316)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The European Green Deal: shaping environmentally friendly policies under Article 101 TFEU
Market and Competition Law Review, 2020 In the light of the renewed general interest for environmental issues, resulting from the launch of the European Green Deal by President Von Der Leyen, the paper explores how the EU Commission could promote environmental considerations in the ...
Andrea Pezza
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
ANALYSIS OF FACTORS DEPENDING INNOVATIVE ACTIVITY OF ORGANIZATIONS OF MOSCOW REGION
Статистика и экономика, 2016 The article gives a detailed analysis ofthe views of the organizations surveyedby economic activity. Due to the fact that the share of the manufacturing sector ofthe Moscow region in 2012.
Svetlana N. Zhuravlev
doaj +1 more source
THE ESSENCE OF COMPETITIVENESS, COMPETITIVE ADVANTAGES AND COMPETITIVE STRATEGIES
, 2023 The article discusses the concept of competition, the main features of competition, and types of competition. An analysis was carried out, positive and negative aspects were identified.
openaire +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
COMPETITION ASPECTS IN THE AI ACT – NAVIGATING THE MURKY WATERS OF THE ABUSIVE PRACTICES IN A DECENTRALISED VIRTUAL WORLD [PDF]
Challenges of the Knowledge SocietyThe whole European construction, based on the three initial European Communities (namely, the European Coal and Steel Community, the European Economic Community and the European Atomic Energy Community) were built with several goals in mind, one of ...
Iulian BĂICULESCU
doaj
Strategic Polish State Enterprise (SOE) on the list of the largest European companies
Journal of Modern ScienceObjectives In 2023, only eight Polish enterprises were listed on the Fortune Europe 500, of which seven were classified as State-Owned Enterprises (SOEs). They ranked quite low on the list. The article aims to identify the crucial factors influencing the
Teresa Pakulska +1 more
doaj +1 more source
International Competition Policy Advisory Committee: Antitrust Division
, 1998 The International Competition Policy Advisory Committee (ICPAC) was formed in November 1997 to address the global antitrust problems of the 21st ...
DOJ/ATR International Competition Policy Advisory Committee
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