PROBLEMS OF INTEGRAL STATISTICAL EVALUATION OF SOCIAL-ECONOMIC DEVELOPMENT REGION
In recent years, increased attention is paidto the various aspects of applied analysisof individual subjects of our country. In thiscontext, the great scientific and practicalinterest is the systematization of problemsgeneralizing the statistical ...
Elena N. Volkova
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Understanding the processing of sexual stimuli has become a significant part of research on human sexuality. In addition to individual characteristics (gender and sexual orientation), empirical studies have shown that cultural factors play an important ...
Qianqian Cui +4 more
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In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
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GUARANTEEING THE ACCES OF THIRD PARTIES TO THE NETWORK INDUSTRIES SPECIFIC INFRASTRUCTURES – A VITAL COMPONENT OF EU'S POLICY IN THE FIELD OF COMPETITION ON THE ENERGY MARKET, IN THE CONTEXT OF THE NEED TO INSURE ENERGY INDEPENDENCE WHILE MANTAINING AFFORDABLE PRICES [PDF]
As both the practical experience and the theoretical constructions of successive generations of practitioners and researchers of the phenomenon of the economy and the legal norms associated with its proper functioning have proven, the most important ...
Iulian BĂICULESCU +1 more
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Omówienie prac nad implementacją dyrektywy 2014/104/UE w Polsce, Hiszpanii i Wielkiej Brytanii [PDF]
Artykuł prezentuje wybrane zagadnienia związane z implementacją Dyrektywy Parlamentu Europejskiego i Rady 2014/104/UE z 26 listopada 2014 r. w sprawie niektórych przepisów regulujących dochodzenie roszczeń odszkodowawczych z tytułu naruszenia prawa ...
Jacek Sadurski
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
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Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
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Is vertical separation a prerequisite to enhancing competition in the South African energy industry?
Vertical separation is believed to have positive effects in energy sectors where certain phases of the value chain operate under a natural monopoly.
Thembalethu Sithebe, Tshekishi Kolobe
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