Results 81 to 90 of about 1,250,387 (316)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Google Adtech – Break Up or Break Out?
Utrecht Law ReviewThe European Commission recently proposed a break up of Google’s display advertising business. We argue that the market definition used by the Commission risks being too narrow and propose expanding it to include Google’s broader ecosystem. We then ask a
Todd Davies, Zlatina Georgieva
doaj +1 more source
Статистика и экономика, 2016 The study volume, structure and dynamics of investment companies Moscow region will be carried out using the methods ofeconomic-statistical, financial and economic analysis, includingmethods of statistical observation methods grouping detail anddata ...
Svetlana N. Zhuravleva
doaj +1 more source
Decision-making powers and institutional design in competition cases: the Brazilian experience
, 2014 Conteúdo online de acesso restrito pelo editorThis article discusses the experience of Brazil regarding institutional design and decision-making powers and Brazil's efforts to enhance its convergence to international best practices, thereby improving ...
Araujo, Mariana Tavares de +1 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
sprynger: Scriptable bibliometrics using a Python interface to Springer Nature
SoftwareXWe present a wrapper for the Springer Nature RESTful API written for Python 3. The wrapper allows users to access their free-to-use endpoints via user-friendly interfaces and can be used without prior knowledge of RESTful APIs.
Nils A. Herrmann, Michael E. Rose
doaj +1 more source
Market and Competition Law Review, 2019 The article analyses the recent judgment of the Court of Justice of the European Union (CJEU) in Skanska Industrial. In its preliminary ruling, the CJEU recognised for the first time the so-called “economic succession doctrine” in damage claims ...
Marco Botta
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source