Grand challenges for the spatial information community
Journal of Spatial Information Science, 2020 The spatial information (SI) community has an opportunity to address major societal and scientific problems including public health, climate change, air pollution, transportation, and others. Beyond the significant contributions made by the SI community,
Leye Wang, Ouri Wolfson
doaj +1 more source
Effects of temporal variability on rare plant persistence in annual [PDF]
, 2004 Traditional conservation biology regards environmental fluctuations as detrimental to persistence, reducing long-term average growth rates and increasing the probability of extinction.
Levine, J.M., Rees, M.
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A simple rule for the evolution of fast dispersal at the edge of expanding populations [PDF]
, 2019 Evolution by natural selection is commonly perceived as a process that favors those that replicate faster to leave more offspring; nature, however, seem to abound with examples where organisms forgo some replicative potential to disperse faster.
Carmona-Fontaine, Carlos +3 more
core
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations
, 2012 Mutations create the genetic diversity on which selective pressures can act, yet also create structural instability in proteins. How, then, is it possible for organisms to ameliorate mutation-induced perturbations of protein stability while maintaining ...
Benkovic +29 more
core +1 more source
Proof of principle : the adaptive geometry of social foragers [PDF]
, 2016 Acknowledgments We thank Cape Nature for permission to undertake the study. We thank Dr Matt Grove and two anonymous referees for comments and suggestions that improved the manuscript substantially.
Barrett, Louise +7 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Improving deconvolution methods in biology through open innovation competitions: an application to the connectivity map [PDF]
, 2021 Andrea Blasco +11 more
openalex +1 more source
Modelling and measuring intracellular competition for finite resources during gene expression
Journal of the Royal Society Interface, 2019 Dissecting the competition between genes for shared expressional resources is of fundamental importance for understanding the interplay between cellular components.
R. Sabi, T. Tuller
semanticscholar +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source