Results 101 to 110 of about 2,456,397 (363)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Contrasting impacts of competition on ecological and social trait evolution in songbirds

PLoS Biology, 2018
Competition between closely related species has long been viewed as a powerful selective force that drives trait diversification, thereby generating phenotypic diversity over macroevolutionary timescales.
J. Drury, J. Tobias, K. Burns, Nicholas A. Mason, Allison J. Shultz, H. Morlon   +5 more
semanticscholar   +1 more source

An Overview of Agent-Based Models in Plant Biology and Ecology.

Annals of Botany, 2020
Agent-based modeling (ABM) has become an established methodology in many areas of biology, ranging from the cellular to the ecological population and community levels. In plant science, two different scales have predominated in their use of ABM.
Bo Zhang, D. DeAngelis
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Comparison between Effects of Retroactivity and Resource Competition upon Change in Downstream Reporter Genes of Synthetic Genetic Circuits

Life, 2019
Reporter genes have contributed to advancements in molecular biology. Binding of an upstream regulatory protein to a downstream reporter promoter allows quantification of the activity of the upstream protein produced from the corresponding gene.
Takefumi Moriya, Tomohiro Yamaoka, Yuki Wakayama, Shotaro Ayukawa, Zicong Zhang, Masayuki Yamamura, Shinji Wakao, Daisuke Kiga   +7 more
doaj   +1 more source

Kinetic modelling of competition and depletion of shared miRNAs by competing endogenous RNAs

, 2018
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended ...
A Arvey, A Baccarini, A Fatica, A Franks, A Helwak, A Joshi, A Loinger, A Martirosyan, A Martirosyan, A Nadal, A Raveh, A Re, A Riba, A Sanchez, A Sanchez-Mejias, AD Bosson, AK Leung, AM Gurtan, AS Flynt, B Du, B Obermayer, C Bosia, C Bosia, C Bosia, CW Hsu, D Baek, D Kim, DP Bartel, DP Bartel, DP Bartel, DT Gillespie, E Anastasiadou, E Berezikov, E Koller, E Levine, E Levine, FA Karreth, G Tkacik, H Liang, H Teimouri, I Alvarez-Garcia, I Bose, I Legnini, J Breda, J Das, J Fiorentino, J Kwon, J Noorbakhsh, J Tsang, JM Franco-Zorrilla, JM Schmiedel, L López-Maury, L Salmena, L Tsimring, M Chekulaeva, M Figliuzzi, M Figliuzzi, M Gerstein, M Jens, M Klein, M Mauri, M Nitzan, M Osella, M Osella, M Samoilov, MA Gibson, MA Valencia-Sanchez, MS Ebert, MS Ebert, NG Kampen Van, P Flondor, P Mehta, P Sumazin, PB Detwiler, PS Swain, R Denzler, R Denzler, RC Brewster, RC Friedman, RI Gregory, S Djuranovic, S Grigolon, S Guil, S Jonas, S Mukherji, S Pitchiaya, S Sass, S Wang, SD Chandradoss, TB Hansen, TR Cech, U Ala, U Alon, V Siciliano, X Lai, X Wang, X Yuan, Y Liang, Y Shimoni, Y Tay, Y Tay, Y Yuan   +101 more
core   +2 more sources

Of hummingbirds and helicopters: Hovering costs, competitive ability, and foraging strategies [PDF]

, 2004
Wing morphology and flight kinematics profoundly influence foraging costs and the overall behavioral ecology of hummingbirds. By analogy with helicopters, previous energetic studies have applied the momentum theory of aircraft propellers to estimate ...
Altshuler, Douglas L., Dudley, Robert, Stiles, F. Gary   +2 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Towards the Development of an Evolutionarily Valid Domain-Specific Risk-Taking Scale

Evolutionary Psychology, 2007
From an evolutionary perspective, human risk-taking behaviors should be viewed in relation to evolutionarily recurrent survival and reproductive problems.
Daniel J. Kruger, X.T. Wang, Andreas Wilke   +2 more
doaj   +1 more source

Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications

Journal of Biological Engineering, 2018
Background Biosafety is a key aspect in the international Genetically Engineered Machine (iGEM) competition, which offers student teams an amazing opportunity to pursue their own research projects in the field of Synthetic Biology.
Christopher M. Whitford, Saskia Dymek, Denise Kerkhoff, Camilla März, Olga Schmidt, Maximilian Edich, Julian Droste, Boas Pucker, Christian Rückert, Jörn Kalinowski   +9 more
doaj   +1 more source