Results 101 to 110 of about 231,421 (295)

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Improving deconvolution methods in biology through open innovation competitions: an application to the connectivity map [PDF]

, 2021
Andrea Blasco, Ted Natoli, Michael G. Endres, Rinat A. Sergeev, Steven Randazzo, Jin H. Paik, N. J. Maximilian Macaluso, Rajiv Narayan, Xiaodong Lü, D. D. Peck, Karim R. Lakhani, Aravind Subramanian   +11 more
openalex   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Sportwissenschaft

Deutsche Zeitschrift für Sportmedizin, 2016
We assessed whetherthe seasonal training pattern of endurance athletes produces corresponding adaptations of mitochondrial, angiogenic, and myogenic processes in skeletal muscle and whether these relate to the training volume and metabolic load during ...
Frese S, 2, Valdivieso P, Jaecker VC, Harms SA, Konou TM, Tappe KA, Schiffer T, Frese L, Bloch W, 6, Flück M, 7   +12 more
doaj   +1 more source

Competition in a Fitness Landscape [PDF]

Fourth European Conference on Artificial Life, P. Husbands and I. Harvey (eds.), The MIT Press (Cambridge, Massachussets, 1997) p. 101, 1997
We present an extension of Eigen's model for quasi-species including the competition among individuals, proposed as the simplest mechanism for the formation of new species in a smooth fitness landscape. We are able to obtain analytically the critical threshold for species formation. The comparison with numerical simulations is very good.
arxiv  

An enzyme‐linked immunosorbent assay (ELISA)‐based activity assay for AMP‐activated protein kinase (AMPK)

FEBS Open Bio, EarlyView.
Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley   +1 more source

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

An axiomatic theory for interaction between species in ecology: Gause's exclusion conjecture [PDF]

arXiv, 2006
I introduce an axiomatic representation, called ecoset, to consider interactions between species in ecological systems. For interspecific competition, the exclusion conjecture (Gause) is put in a symbolic way and used as a basic operational tool to consider more complex cases like two species with two superposed resources (niche differentiation) and ...
arxiv  

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source