Results 71 to 80 of about 361,461 (265)

Strategies for Competitive Activity-Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization. [PDF]

Isr J Chem, 2023
Zhu H, Sharafi M, Teh WP, Bratt AS, Buhrlage SJ, Marto JA.   +5 more
europepmc   +1 more source

Non‐Competitive Inhibition by Active Site Binders [PDF]

Chemical Biology & Drug Design, 2010
Classical enzymology has been used for generations to understand the interactions of inhibitors with their enzyme targets. Enzymology tools enabled prediction of the biological impact of inhibitors as well as the development of novel, more potent, ones.
openaire   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling. [PDF]

Cell Chem Biol, 2022
Li M, Patel HV, Cognetta AB, Smith TC, Mallick I, Cavalier JF, Previti ML, Canaan S, Aldridge BB, Cravatt BF, Seeliger JC.   +10 more
europepmc   +1 more source

Competitive Live Evaluations of Activity-Recognition Systems

IEEE Pervasive Computing, 2015
In order to ensure the validity and usability of activity recognition approaches, an agreement on a set of standard evaluation methods is needed. Due to the diversity of the sensors and other hardware employed, designing and accepting standard tests is a difficult task.
Gjoreski, Hristijan, Kozina, Simon, Gams, Matjaž, Luštrek, Mitja, Álvarez García, Juan Antonio, Hong, Jin-Hyuk, Ramos, Julian, Dey, Anind K., Bocca, Maurizio, Patwari, Neal   +9 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Indicators of Spectacle in Wrestling at the 2021 Olympic Games

Слобожанський науково-спортивний вісник
Background and Study: Spectacle plays a key role in sports wrestling in attracting viewers' attention, creating emotional involvement, and making the sport an integral part of culture.
Rashid Matkarimov, Georgiy Korobeynikov, Yrui Tropin, Viktoriia Biletska, David Curby, Milorad Dokmanac, Fikrat Kerimov   +6 more
doaj   +1 more source

Is Self-Sacrificial Competitive Altruism Primarily a Male Activity?

Evolutionary Psychology, 2012
This study explored the basis of self-sacrificial prosocial behavior in small groups. Seventy-eight undergraduates (39M, 39F) filled out a thirty-item personality scale and then participated in a “group problem-solving study” in which the monetary ...
Francis T. McAndrew, Carin Perilloux
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Competition performance of rugby-players of youth championship of Europe U-20. [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
The results of pedagogical supervision and comparative analysis of components of contention activity of the best commands of participants of zonal and final part of championship of Europe are rotined on rugby among masculine youth collapsible commands ...
Kvasnitsa O.M., Bazyl'chuk O.V.
doaj