Results 131 to 140 of about 285,043 (352)

Specific involvement of two amino acid residues in cis -nerolidol binding to odorant-binding protein 5 AlinOBP5 in the alfalfa plant bug, Adelphocoris lineolatus (Goeze)

, 2013
Olfaction plays an important role in insects' survival and reproduction. Odorant-binding proteins (OBPs) are considered to be one of the crucial proteins in the insect olfactory pathway.
S.-H. Gu, Han, L., J.-J. Zhou, Wang, S-Y., Guo, Y-Y., Zhang, Y-J., Gu, S-H., S.-Y. Wang, Y.-J. Zhang, Zhou, J-J., Y.-Y. Guo, L. Han   +11 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Combining Spectroscopic and Potentiometric Approaches to Characterize Competitive Binding to Humic Substances

, 2008
International audienceIn an area that contains high concentrations of natural organic matter, it is expected that it plays an important role on the behavior of rare earth elements (REE), like europium, and of trivalent actinides. Competitive interactions
Marang, Laura, Benedetti, Marc F., Benedetti, Marc, F., Eidner, Sascha, Reiller, Pascal E., Kumke, Michael, Kumke, Michael Uwe (PD Dr.)   +6 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Hsa_circ_0000423 promotes colorectal cancer EMT and immune escape by competitive adsorption of miR-369-3p mediating CCND1 expression

Discover Oncology
Background This investigation evaluated the mechanism of hsa_circ_0000423 in colorectal cancer (CRC). Methods The hsa_circ_0000423 gene was identified by bioinformatics analyses of GEO circRNA microarrays, and its expression in CRC was investigated ...
TianFu Huang, KaiHai Jiang, LinTao Li, GuangSheng Li, YuSheng Cao, XuSen Huang   +5 more
doaj   +1 more source

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action [PDF]

, 2017
James Robinson, Euan W. Baxter, Robin L. Owen, Maren Thomsen, Darren C. Tomlinson, Mark P. Waterhouse, Stephanie J. Win, Joanne E. Nettleship, Christian Tiede, Richard J. Foster, Raymond J. Owens, Colin W. G. Fishwick, Sarah A. Harris, Adrian Goldman, Michael J. McPherson, Ann W Morgan   +15 more
openalex   +1 more source

Competitive Binding of Parkinsonian‐inducing Neurotoxins to Neuromelanin

, 2016
Competitive Binding of Parkinsonian‐inducing Neurotoxins to NeuromelaninHaining, Robert (faculty ...
Hernandez, Aubrey
core  

PKD1 3D Structure Model and Docking Studies for New PKD Inhibitors [PDF]

, 2013
Protein kinase Ds (PKDs) are diacylglycerol (DAG)-regulated serine/threonine protein kinases. In intact cells, PKDs are key mediators in cellular processes pertaining to multiple diseases, including cancer, heart diseases, angiogenesis and immune ...
Xu, Qi
core  

Glucocorticoid-dependent transcriptional repression of the osteocalcin gene by competitive binding at the TATA box

, 1997
The human osteocalcin gene is transcriptionally repressed by glucocorticoids. A specific binding element for the glucocorticoid receptor (GR) overlapping the TATA box of the human osteocalcin promoter has previously been identified. In the present study,
Gustafsson, JA, Meyer, T, Carlstedt-Duke, J,   +2 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source