Results 1 to 10 of about 274,575 (167)
Competitive dCas9 binding as a mechanism for transcriptional control [PDF]
Molecular Systems Biology, 2021 Catalytically dead Cas9 (dCas9) is a programmable transcription factor that can be targeted to promoters through the design of small guide RNAs (sgRNAs), where it can function as an activator or repressor.
Daniel A Anderson, Christopher A Voigt
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Investigate synergistic and competitive regulation between miRNAs by using a multivariate information measurement [PDF]
BMC BioinformaticsMultiple microRNAs can bind to the 3’ untranslated region (3’UTR) of the same mRNA transcript. Depending on the spatial arrangement of their binding sites, endogenous microRNAs may cooperate to enhance repression or compete for overlapping sites ...
Chu Pan, Yanlin Chen, Tianwu Zhang
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Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data [PDF]
PeerJ, 2023 Transcription factor binding to a gene regulatory region induces or represses its expression. Binding and expression target analysis (BETA) integrates the binding and gene expression data to predict this function.
Mahmoud Ahmed, Deok Ryong Kim
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Competitive aptamer switch for modulating ligand binding affinity
Advanced Agrochem, 2023 Aptamers are short, single-stranded DNA or RNA molecules that selectively bind to a target molecule. Aptamer-complement duplex (ACD) is often used to design molecular switches capable of producing a detectable signal or triggering a structural change ...
Derek Puyat +3 more
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Heliyon, 2023 P2X purinoceptor 4 (P2X4) is an ATP-gated ion channel receptor with diverse neurophysiological functions, and P2X4 modulators hold promise as potential therapeutics for neuropathic pain, neuroinflammation, and neurodegenerative diseases.
Tess Puopolo +4 more
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Is styrene competitive for dopamine receptor binding?
Biomolecular Concepts, 2022 The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations.
De Santis Emiliano +4 more
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Competition between LIM-binding domains [PDF]
Biochemical Society Transactions, 2008 LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline +8 more
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Integrating binding and expression data to predict transcription factors combined function
BMC Genomics, 2020 Background Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins. These proteins form complexes
Mahmoud Ahmed +2 more
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Computational fragment-based binding site identification by ligand competitive saturation. [PDF]
PLoS Computational Biology, 2009 Fragment-based drug discovery using NMR and x-ray crystallographic methods has proven utility but also non-trivial time, materials, and labor costs.
Olgun Guvench, Alexander D MacKerell
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Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding
Bio-Protocol, 2014 Lipopolysaccharide is the major constituent of the outer membrane of gram-negative bacteria and, once released from the bacterial surface into the bloodstream, is a potent activator of the host immune system, which can lead to septic shock.
Victoria Martínez-Sernández +1 more
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