Results 21 to 30 of about 2,748,278 (304)

Competition between LIM-binding domains [PDF]

Biochemical Society Transactions, 2008
LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline, Bhati, Mugdha, Craig, Vanessa J, Deane, Janet E, Jeffries, Cy, Lee, Christopher, Nancarrow, Amy L, Ryan, Daniel, Sunde, Margaret   +8 more
openaire   +4 more sources

Integrating binding and expression data to predict transcription factors combined function

BMC Genomics, 2020
Background Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins. These proteins form complexes
Mahmoud Ahmed, Do Sik Min, Deok Ryong Kim   +2 more
doaj   +1 more source

Computational fragment-based binding site identification by ligand competitive saturation. [PDF]

PLoS Computational Biology, 2009
Fragment-based drug discovery using NMR and x-ray crystallographic methods has proven utility but also non-trivial time, materials, and labor costs.
Olgun Guvench, Alexander D MacKerell
doaj   +1 more source

Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding

Bio-Protocol, 2014
Lipopolysaccharide is the major constituent of the outer membrane of gram-negative bacteria and, once released from the bacterial surface into the bloodstream, is a potent activator of the host immune system, which can lead to septic shock.
Victoria Martínez-Sernández, Florencio M Ubeira   +1 more
doaj   +1 more source

Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Molecules, 2022
Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s
Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins   +10 more
doaj   +1 more source

nordenfeltLab/competitive-polyclonal-antibody-binding-model: Initial release

, 2020
competitive-polyclonal-antibody-binding ...
Vibha Kumra Ahnlide
core   +1 more source

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang, Hooper, Tony, Pickett, John, Field, Lin   +23 more
core   +1 more source

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy. [PDF]

, 2022
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation.
Wang, Yingjie, Walker, Caitlin, Kim, Jonggul, De Simone, Alfonso, Vendruscolo, Michele, Olivieri, Cristina, Camilloni, Carlo, Veglia, Gianluigi, Kim J., Taylor, Susan S, Carlo Camilloni, David A. Bernlohr, Taylor S. S., Jonggul Kim, Wang Y., Bernlohr D. A., Alfonso De Simone, Walker C., Bernlohr, David A, Camilloni C., Vendruscolo M., Li G. C., Olivieri C., Geoffrey C. Li, Caitlin Walker, De Simone A., Veglia G., Yingjie Wang, Manu V. S., Susan S. Taylor, Gianluigi Veglia, Cristina Olivieri, Li, Geoffrey C, V S, Manu, Michele Vendruscolo, Manu V.S.   +35 more
core   +3 more sources

Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding [PDF]

The Journal of Immunology, 2014
Abstract Chemokines comprise a family of secreted proteins that activate G protein–coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines to membrane-tethered ...
Verkaar, F., Offenbeek, J. van, Lee (Helen Dowling Instituut), M.L. van der, Lith, L.H. van, Watts, A.O., Rops, A.L., Aguilar, D.C., Ziarek, J.J., Vlag, J. van der, Handel, T.M., Volkman, B.F., Proudfoot, A.E., Vischer, H.F., Zaman, G.J., Smit, M.J.   +14 more
openaire   +4 more sources

Competitive Binding of Natural Amphiphiles with Graphene Derivatives [PDF]

Scientific Reports, 2013
Understanding the transformation of graphene derivatives by natural amphiphiles is essential for elucidating the biological and environmental implications of this emerging class of engineered nanomaterials. Using rapid discrete-molecular-dynamics simulations, we examined the binding of graphene and graphene oxide with peptides, fatty acids, and ...
Radic, Slaven, Geitner, Nicholas K., Podila, Ramakrishna, Kaekinen, Aleksandr, Chen, Pengyu, Ke, Pu Chun, Ding, Feng   +6 more
openaire   +4 more sources