Results 21 to 30 of about 3,754,687 (312)

Computational fragment-based binding site identification by ligand competitive saturation. [PDF]

PLoS Computational Biology, 2009
Fragment-based drug discovery using NMR and x-ray crystallographic methods has proven utility but also non-trivial time, materials, and labor costs.
Olgun Guvench, Alexander D MacKerell
doaj   +1 more source

Competition between LIM-binding domains [PDF]

Biochemical Society Transactions, 2008
LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline, Bhati, Mugdha, Craig, Vanessa J, Deane, Janet E, Jeffries, Cy, Lee, Christopher, Nancarrow, Amy L, Ryan, Daniel, Sunde, Margaret   +8 more
openaire   +4 more sources

Competitive binding predicts nonlinear responses of olfactory receptors to complex mixtures [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Predicting the response of the olfactory system to natural odors, typically complex mixtures of many molecules, is a major challenge. Here, we show that the nonlinear mixing response of many mammalian olfactory receptors is largely explained
Vijay Singh, Nicolle R. Murphy, V. Balasubramanian, J. Mainland   +3 more
semanticscholar   +1 more source

Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding

Msphere, 2020
With the emergence and continued spread of the SARS-CoV-2 virus, and of the associated disease, coronavirus disease 2019 (COVID-19), there is an urgent need for improved understanding of how the body mounts an immune response to the virus.
James R. Byrnes, Xin X. Zhou, Irene Lui, Susanna K. Elledge, J. Glasgow, Shion A. Lim, R. Loudermilk, C. Chiu, Taia T. Wang, M. Wilson, K. Leung, J. Wells   +11 more
semanticscholar   +1 more source

Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding

Bio-Protocol, 2014
Lipopolysaccharide is the major constituent of the outer membrane of gram-negative bacteria and, once released from the bacterial surface into the bloodstream, is a potent activator of the host immune system, which can lead to septic shock.
Victoria Martínez-Sernández, Florencio M Ubeira   +1 more
doaj   +1 more source

Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70

Molecules, 2022
Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s
Suzanne O’Connor, Yann-Vaï Le Bihan, Isaac M. Westwood, Manjuan Liu, Oi Wei Mak, Gabriel Zazeri, Ana P. R. Povinelli, Alan M. Jones, Rob van Montfort, Jóhannes Reynisson, Ian Collins   +10 more
doaj   +1 more source

Involvement of the DNA Phosphorothioation System in TorR Binding and Anaerobic TMAO Respiration in Salmonella enterica

mBio, 2022
Although the phosphorothioate (PT) modification, in which the nonbridging oxygen in the DNA sugar-phosphate backbone is replaced by sulfur, has been reported to play versatile roles in multiple cellular processes, very little data have been obtained to ...
You Tang, Yue Hong, Li Liu, Xuan Du, Yaqi Ren, Susu Jiang, Wanjing Liu, Chen Chao, Zixin Deng, Lianrong Wang, Shi Chen   +10 more
doaj   +1 more source

Competitive interactions of ligands and macromolecular crowders with maltose binding protein. [PDF]

PLoS ONE, 2013
Cellular signaling involves a cascade of recognition events occurring in a complex environment with high concentrations of proteins, polysaccharides, and other macromolecules.
Andrew C Miklos, Matthew Sumpter, Huan-Xiang Zhou   +2 more
doaj   +1 more source

Thrombospondin is a tight-binding competitive inhibitor of neutrophil elastase.

Journal of Biological Chemistry, 1993
Thrombospondin, a glycoprotein of three identical disulfide-bonded subunits, is a constituent of platelet alpha-granules and a variety of normal and transformed cells and binds to cell surfaces and becomes incorporated into extracellular matrix.
P. Hogg, D. Owensby, D. Mosher, T. M. Misenheimer, C. Chesterman   +4 more
semanticscholar   +1 more source

Discrimination of Oviposition Deterrent Volatile β-Ionone by Odorant-Binding Proteins 1 and 4 in the Whitefly Bemisia tabaci

Biomolecules, 2019
: The whitefly, Bemisia tabaci, is an important invasive economic pest of agricultural crops worldwide. β-ionone has a significant oviposition repellent effect against B. tabaci, but the olfactory molecular mechanism of this insect for recognizing &#
Fengqi Li, Du Li, Youssef Dewer, Cheng Qu, Zhen Yang, Jiahui Tian, Chen Luo   +6 more
doaj   +1 more source