Results 21 to 30 of about 2,617,421 (301)

Competitive interactions of ligands and macromolecular crowders with maltose binding protein. [PDF]

PLoS ONE, 2013
Cellular signaling involves a cascade of recognition events occurring in a complex environment with high concentrations of proteins, polysaccharides, and other macromolecules.
Andrew C Miklos, Matthew Sumpter, Huan-Xiang Zhou   +2 more
doaj   +1 more source

High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]

, 2011
Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan, Robert B. Sim, Russell Wallis, Tan, Bee K., Elizabeth J. Soilleux, Townsend, Paul, Wallis, Russell, Soilleux, Elizabeth J., Paul Townsend, Daniel A. Mitchell, Randeva, Harpal S., Sim, Robert B., Hendrik Lehnert, Ilyas, Rebecca, Zehnder, Daniel, Mitchell, Daniel A., Daniel Zehnder, Rebecca Ilyas, Harpal S. Randeva, Lehnert, Hendrik   +19 more
core   +1 more source

Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding [PDF]

The Journal of Immunology, 2014
Abstract Chemokines comprise a family of secreted proteins that activate G protein–coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines to membrane-tethered ...
Verkaar, F., Offenbeek, J. van, Lee (Helen Dowling Instituut), M.L. van der, Lith, L.H. van, Watts, A.O., Rops, A.L., Aguilar, D.C., Ziarek, J.J., Vlag, J. van der, Handel, T.M., Volkman, B.F., Proudfoot, A.E., Vischer, H.F., Zaman, G.J., Smit, M.J.   +14 more
openaire   +4 more sources

Home Economics at Swiss Secondary Schools (HESSS)

, 2023
The Home Economics at Swiss Secondary Schools (HESSS) dataset covers the provision of home economics education in ten German-speaking cantons in Switzerland for vocational- and university track secondary schools since 1980 and 1991, respectively.
Grob, Anja, Spirig, Judith, Binding, Garret   +2 more
core   +1 more source

Replication data for: The Comparative Meaning of Political Space: A Comprehensive Modeling Approach

, 2023
In latent scaling applications, such as the positioning of political parties, differential item functioning (DIF) may occur because of measurement issues or because of substantive differences in the association between latent and manifest variables ...
Steenbergen, Marco, Koedam, Jelle, Binding, Garret   +2 more
core   +1 more source

Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol

IUCrJ, 2021
Death-associated protein kinase 1 (DAPK1) is a large multidomain protein with an N-terminal serine/threonine protein kinase domain. DAPK1 is considered to be a promising molecular target for the treatment of Alzheimer's disease (AD). In the present study,
Takeshi Yokoyama, Ryoya Suzuki, Mineyuki Mizuguchi   +2 more
doaj   +1 more source

Competitive Binding of Natural Amphiphiles with Graphene Derivatives [PDF]

Scientific Reports, 2013
Understanding the transformation of graphene derivatives by natural amphiphiles is essential for elucidating the biological and environmental implications of this emerging class of engineered nanomaterials. Using rapid discrete-molecular-dynamics simulations, we examined the binding of graphene and graphene oxide with peptides, fatty acids, and ...
Radic, Slaven, Geitner, Nicholas K., Podila, Ramakrishna, Kaekinen, Aleksandr, Chen, Pengyu, Ke, Pu Chun, Ding, Feng   +6 more
openaire   +4 more sources

Competitive Priorities and Competitive Advantage in Jordanian Manufacturing [PDF]

, 2013
The purpose of this research was to explore and predict the relationship between the competitive priorities (quality, cost, flexibility and delivery) and the competitive advantage of firms in the Jordanian Industrial Sector.
Al Khattab, Adel A., Awwad, Abdulkareem S., Anchor, J.R   +2 more
core   +1 more source

A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry

Frontiers in Chemistry, 2019
The primary objective of early drug development is to identify hits and leads for a target of interest. To achieve this aim, rapid, and reliable screening techniques for a huge number of compounds are needed.
Jürgen Gabriel, Georg Höfner, Klaus T. Wanner   +2 more
doaj   +1 more source

Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier

Frontiers in Pharmacology, 2022
Our group has developed and experimentally validated a strategy to increase antibody penetration in solid tumors through transient inhibition of antibody-antigen binding. In prior work, we demonstrated that 1HE, an anti-trastuzumab single domain antibody
Brandon M. Bordeau, Lubna Abuqayyas, Toan D. Nguyen, Ping Chen, Joseph P. Balthasar   +4 more
doaj   +1 more source