Results 31 to 40 of about 3,754,687 (312)

Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores. [PDF]

PLoS ONE, 2010
In an analytical model channel transport is analyzed as a function of key parameters, determining efficiency and selectivity of particle transport in a competitive molecular environment.
Wolfgang R Bauer, Walter Nadler
doaj   +1 more source

Crystal structure of death-associated protein kinase 1 in complex with the dietary compound resveratrol

IUCrJ, 2021
Death-associated protein kinase 1 (DAPK1) is a large multidomain protein with an N-terminal serine/threonine protein kinase domain. DAPK1 is considered to be a promising molecular target for the treatment of Alzheimer's disease (AD). In the present study,
Takeshi Yokoyama, Ryoya Suzuki, Mineyuki Mizuguchi   +2 more
doaj   +1 more source

Rationally introduce multi-competitive binding interactions in supramolecular gels: a simple and efficient approach to develop multi-analyte sensor array

Chemical Science, 2016
A supramolecular-gel-based twenty-two-member sensor array has been created by introducing well-designed multi-competitive binding interactions into a supramolecular gel.
Qi Lin, Tao-Tao Lu, Xin Zhu, T. Wei, Hui Li, You‐Ming Zhang   +5 more
semanticscholar   +1 more source

A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry

Frontiers in Chemistry, 2019
The primary objective of early drug development is to identify hits and leads for a target of interest. To achieve this aim, rapid, and reliable screening techniques for a huge number of compounds are needed.
Jürgen Gabriel, Georg Höfner, Klaus T. Wanner   +2 more
doaj   +1 more source

Defining TP53 pioneering capabilities with competitive nucleosome binding assays

Genome Research, 2018
Accurate gene expression requires the targeting of transcription factors (TFs) to regulatory sequences often occluded within nucleosomes. The ability to target a TF binding site (TFBS) within a nucleosome has been the defining characteristic for a ...
Xinyang Yu, M. Buck
semanticscholar   +1 more source

Establishment of competitive binding assay to detect and differentiate hepatitis E virus infection

Annals of Hepatology, 2019
Introduction and Objectives: This study was undertaken to demonstrate a promising approach for detection and differentiation the serum immunoglobulin G (IgG) against hepatitis E virus (anti-HEV IgG) using a competitive binding assay established with ...
Jiyue Wen, Weizhuo Lu, Jihong Meng
doaj   +1 more source

Development and Evaluation of Competitive Inhibitors of Trastuzumab-HER2 Binding to Bypass the Binding-Site Barrier

Frontiers in Pharmacology, 2022
Our group has developed and experimentally validated a strategy to increase antibody penetration in solid tumors through transient inhibition of antibody-antigen binding. In prior work, we demonstrated that 1HE, an anti-trastuzumab single domain antibody
Brandon M. Bordeau, Lubna Abuqayyas, Toan D. Nguyen, Ping Chen, Joseph P. Balthasar   +4 more
doaj   +1 more source

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

Antiviral Research, 2020
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented rate.
S. Kim, Weihua Jin, Amika K. Sood, David W. Montgomery, Oliver C. Grant, M. Fuster, Li Fu, J. Dordick, R. Woods, Fuming Zhang, R. Linhardt   +10 more
semanticscholar   +1 more source

6-Arylpyrido[2,3-d]pyrimidines as novel ATP-competitive inhibitors of bacterial D-alanine:D-alanine ligase. [PDF]

PLoS ONE, 2012
BACKGROUND: ATP-dependent D-alanine:D-alanine ligase (Ddl) is a part of biochemical machinery involved in peptidoglycan biosynthesis, as it catalyzes the formation of the terminal D-ala-D-ala dipeptide of the peptidoglycan precursor UDPMurNAc ...
Veronika Škedelj, Emilija Arsovska, Tihomir Tomašić, Ana Kroflič, Vesna Hodnik, Martina Hrast, Marija Bešter-Rogač, Gregor Anderluh, Stanislav Gobec, Julieanne Bostock, Ian Chopra, Alex J O'Neill, Christopher Randall, Anamarija Zega   +13 more
doaj   +1 more source

Effects of combined binding of chlorogenic acid/caffeic acid and gallic acid to trypsin on their synergistic antioxidant activity, enzyme activity and stability

Food Chemistry: X, 2023
The combined application of multiple natural polyphenols in functional foods may provide better health benefits. The binding of polyphenols with different structures to proteins will affect their respective functions.
Xin Qi, He Liu, Yongfang Ren, Yihao Zhu, Qiulu Wang, Yanqing Zhang, Yushu Wu, Lixia Yuan, Hui Yan, Min Liu   +9 more
doaj   +1 more source