Results 11 to 20 of about 3,754,687 (312)

Competitive dCas9 binding as a mechanism for transcriptional control [PDF]

Molecular Systems Biology, 2021
Catalytically dead Cas9 (dCas9) is a programmable transcription factor that can be targeted to promoters through the design of small guide RNAs (sgRNAs), where it can function as an activator or repressor.
Daniel A Anderson, Christopher A Voigt
doaj   +3 more sources

Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding [PDF]

The Journal of Immunology, 2014
Abstract Chemokines comprise a family of secreted proteins that activate G protein–coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines to membrane-tethered ...
Verkaar, F., Offenbeek, J. van, Lee (Helen Dowling Instituut), M.L. van der, Lith, L.H. van, Watts, A.O., Rops, A.L., Aguilar, D.C., Ziarek, J.J., Vlag, J. van der, Handel, T.M., Volkman, B.F., Proudfoot, A.E., Vischer, H.F., Zaman, G.J., Smit, M.J.   +14 more
openaire   +5 more sources

Competitive Binding of Natural Amphiphiles with Graphene Derivatives [PDF]

Scientific Reports, 2013
Understanding the transformation of graphene derivatives by natural amphiphiles is essential for elucidating the biological and environmental implications of this emerging class of engineered nanomaterials. Using rapid discrete-molecular-dynamics simulations, we examined the binding of graphene and graphene oxide with peptides, fatty acids, and ...
Radic, Slaven, Geitner, Nicholas K., Podila, Ramakrishna, Kaekinen, Aleksandr, Chen, Pengyu, Ke, Pu Chun, Ding, Feng   +6 more
openaire   +5 more sources

Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data [PDF]

PeerJ, 2023
Transcription factor binding to a gene regulatory region induces or represses its expression. Binding and expression target analysis (BETA) integrates the binding and gene expression data to predict this function.
Mahmoud Ahmed, Deok Ryong Kim
doaj   +2 more sources

Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking

Heliyon, 2023
P2X purinoceptor 4 (P2X4) is an ATP-gated ion channel receptor with diverse neurophysiological functions, and P2X4 modulators hold promise as potential therapeutics for neuropathic pain, neuroinflammation, and neurodegenerative diseases.
Tess Puopolo, Ang Cai, Chang Liu, Hang Ma, Navindra P. Seeram   +4 more
doaj   +1 more source

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy

Science Advances, 2022
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation.
C. Olivieri, Geoffrey C. Li, Yingjie Wang, M. V S, Caitlin Walker, Jonggul Kim, C. Camilloni, Alfonso De Simone, M. Vendruscolo, D. Bernlohr, Susan S. Taylor, G. Veglia   +11 more
semanticscholar   +1 more source

Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2

Cells, 2021
Non-alcoholic fatty liver disease (NAFLD) is a global clinical problem. The MD2-TLR4 pathway exacerbates NAFLD progression by promoting inflammation. Long-term exercise is considered to improve NAFLD but the underlying mechanism is still unclear. In this
Weiwei Zhu, Namood E Sahar, Hafiz Muhammad Waseem Javaid, E. S. Pak, G. Liang, Yi Wang, H. Ha, J. Huh   +7 more
semanticscholar   +1 more source

Competitive aptamer switch for modulating ligand binding affinity

Advanced Agrochem, 2023
Aptamers are short, single-stranded DNA or RNA molecules that selectively bind to a target molecule. Aptamer-complement duplex (ACD) is often used to design molecular switches capable of producing a detectable signal or triggering a structural change ...
Derek Puyat, Sung Won Oh, Shiming Liu, Jinglin Fu, Ph.D   +3 more
doaj   +1 more source

Is styrene competitive for dopamine receptor binding?

Biomolecular Concepts, 2022
The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations.
De Santis Emiliano, Minicozzi Velia, Rossi Giancarlo, Stellato Francesco, Morante Silvia   +4 more
doaj   +1 more source

Integrating binding and expression data to predict transcription factors combined function

BMC Genomics, 2020
Background Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins. These proteins form complexes
Mahmoud Ahmed, Do Sik Min, Deok Ryong Kim   +2 more
doaj   +1 more source