Results 1 to 10 of about 2,770,096 (297)
mAbs, 2022 Therapeutic monoclonal antibodies (mAbs) have a propensity to host a large number of chemical and enzymatical modifications that need to be properly assessed for their potential impact on target binding.
Zhengqi Zhang +3 more
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Competitive dCas9 binding as a mechanism for transcriptional control [PDF]
Molecular Systems Biology, 2021 Catalytically dead Cas9 (dCas9) is a programmable transcription factor that can be targeted to promoters through the design of small guide RNAs (sgRNAs), where it can function as an activator or repressor.
Daniel A Anderson, Christopher A Voigt
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A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity [PDF]
Frontiers in Immunology, 2022 Accurate detection of SARS-CoV-2 neutralizing antibody (nAb) is critical for assessing the immunity levels after virus infection or vaccination. As fast, cost-effective alternatives to viral infection-based assays, competitive binding (CB) assays were ...
Xiangyu Yao +17 more
doaj +2 more sources
mBio, 2022 Although the phosphorothioate (PT) modification, in which the nonbridging oxygen in the DNA sugar-phosphate backbone is replaced by sulfur, has been reported to play versatile roles in multiple cellular processes, very little data have been obtained to ...
You Tang +10 more
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Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data [PDF]
PeerJ, 2023 Transcription factor binding to a gene regulatory region induces or represses its expression. Binding and expression target analysis (BETA) integrates the binding and gene expression data to predict this function.
Mahmoud Ahmed, Deok Ryong Kim
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A Polarity-Sensitive Far-Red Fluorescent Probe for Glucose Sensing through Skin
Biosensors, 2023 The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important to continuously track the glucose level to provide better management of the disease.
Lydia Colvin +4 more
doaj +1 more source
Journal of Functional Biomaterials, 2023 Currently available hemodialysis (HD) membranes are unable to safely remove protein-bound uremic toxins (PBUTs), especially those bonded to human serum albumin (HSA).
Madalena Lopes +3 more
doaj +1 more source
mAbs, 2021 Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins.
Rachel Liuqing Shi +5 more
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Molecules, 2022 The interaction of common anticancer drug gemcitabine with human serum albumin (HSA) has been studied in detail. The effect of an omnipresent nonsteroidal anti-inflammatory drug ibuprofen was also seen on the binding of HSA and gemcitabine.
Mohd Sajid Ali, Hamad A. Al-Lohedan
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Competition between LIM-binding domains [PDF]
Biochemical Society Transactions, 2008 LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline +8 more
openaire +4 more sources