Results 1 to 10 of about 285,043 (352)

A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity [PDF]

Frontiers in Immunology, 2022
Accurate detection of SARS-CoV-2 neutralizing antibody (nAb) is critical for assessing the immunity levels after virus infection or vaccination. As fast, cost-effective alternatives to viral infection-based assays, competitive binding (CB) assays were ...
Xiangyu Yao, Zhichao Zhang, Qingmin Mei, Shenwei Li, Li Xing, Li Xing, Yali Long, Demei Zhang, Jing Wang, Xiedong Wang, Bin Xie, Bo Yang, Bo Yang, Yong Gao, Changxin Wu, Changxin Wu, Qinglai Meng, Qinglai Meng   +17 more
doaj   +2 more sources

A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies [PDF]

mAbs, 2022
Therapeutic monoclonal antibodies (mAbs) have a propensity to host a large number of chemical and enzymatical modifications that need to be properly assessed for their potential impact on target binding.
Zhengqi Zhang, Yuetian Yan, Shunhai Wang, Ning Li   +3 more
doaj   +2 more sources

bindNode24: Competitive binding residue prediction with 60 % smaller model [PDF]

Computational and Structural Biotechnology Journal
Many proteins function through ligand binding. Yet, reliable experimental binding data remains limited. Recent advances predict binding residues from sequences using protein Language Model embeddings.
Kyra Erckert, Franz Birkeneder, Burkhard Rost   +2 more
doaj   +2 more sources

CLASP-mediated competitive binding in protein condensates directs microtubule growth [PDF]

Nature Communications
Microtubule organization in cells relies on targeting mechanisms. Cytoplasmic linker proteins (CLIPs) and CLIP-associated proteins (CLASPs) are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we reveal that
Xuanyan Jia, Leishu Lin, Siqi Guo, Lulu Zhou, Gaowei Jin, Jiayuan Dong, Jinman Xiao, Xingqiao Xie, Yiming Li, Sicong He, Zhiyi Wei, Cong Yu   +11 more
doaj   +2 more sources

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy

, 2022
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation.
Cristina Olivieri, Geoffrey Li, Yingjie Wang, Manu Veliparambil Subrahmanian, Caitlin Walker, Jonggul Kim, Carlo Camilloni, Alfonso De Simone, Michele Vendruscolo, David Bernlohr, Susan S. Taylor, Gianluigi Veglia   +11 more
core   +4 more sources

Competitive binding of two drugs for a single binding site on albumin: a circular dichroic study [PDF]

, 1973
Sulphaethidole has been previously shown to have two classes of binding site on bovine serum albumin (BSA). Only the primary binding site is capable of inducing optical activity in the drug.
J.H. Perrin, Dale A. Nelson
openalex   +2 more sources

Buffer and Salt Effects in Aqueous Host-Guest Systems: Screening, Competitive Binding, or Both? [PDF]

J Am Chem Soc, 2021
Jordan JH, Ashbaugh HS, Mague JT, Gibb BC.   +3 more
europepmc   +2 more sources

Corrigendum: P14AS upregulates gene expression in the CDKN2A/2B locus through competitive binding to PcG protein CBX7. [PDF]

Front Cell Dev Biol, 2022
Li Z, Qiao J, Ma W, Zhou J, Gu L, Deng D, Zhang B.   +6 more
europepmc   +3 more sources

Corrigendum to "Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52" [J. Pharm. Anal. 14 (2024) 86-99]. [PDF]

J Pharm Anal
Li S, Gao X, Zheng Y, Yang Y, Gao J, Geng D, Guo L, Ma T, Hao Y, Wei B, Huang L, Wei Y, Xia B, Luo Z, Huang J.   +14 more
europepmc   +2 more sources

Involvement of the DNA Phosphorothioation System in TorR Binding and Anaerobic TMAO Respiration in Salmonella enterica

mBio, 2022
Although the phosphorothioate (PT) modification, in which the nonbridging oxygen in the DNA sugar-phosphate backbone is replaced by sulfur, has been reported to play versatile roles in multiple cellular processes, very little data have been obtained to ...
You Tang, Yue Hong, Li Liu, Xuan Du, Yaqi Ren, Susu Jiang, Wanjing Liu, Chen Chao, Zixin Deng, Lianrong Wang, Shi Chen   +10 more
doaj   +1 more source