High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]
, 2011 Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan +19 more
core +1 more source
Molecular Mechanisms Underlying Inhibitory Binding of Alkylimidazolium Ionic Liquids to Laccase
Molecules, 2017 Water-miscible alkylimidazolium ionic liquids (ILs) are “green” co-solvents for laccase catalysis, but generally inhibit enzyme activity. Here, we present novel insights into inhibition mechanisms by a combination of enzyme kinetics analysis and ...
Jianliang Sun +4 more
doaj +1 more source
Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding [PDF]
The Journal of Immunology, 2014 Abstract Chemokines comprise a family of secreted proteins that activate G protein–coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines to membrane-tethered ...
Verkaar, F. +14 more
openaire +4 more sources
Dually Labeled Biomolecules for Characterizing Biotinylated Species through Competitive Binding Reactions [PDF]
ACS Omega, 2020 Yan Xu, Yuli Pan, Lingnuo Li, Ming Zhou
doaj +2 more sources
Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding
Bio-Protocol, 2014 Lipopolysaccharide is the major constituent of the outer membrane of gram-negative bacteria and, once released from the bacterial surface into the bloodstream, is a potent activator of the host immune system, which can lead to septic shock.
Victoria Martínez-Sernández +1 more
doaj +1 more source
Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70
Molecules, 2022 Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s
Suzanne O’Connor +10 more
doaj +1 more source
Competitive Binding of Natural Amphiphiles with Graphene Derivatives [PDF]
Scientific Reports, 2013 Understanding the transformation of graphene derivatives by natural amphiphiles is essential for elucidating the biological and environmental implications of this emerging class of engineered nanomaterials. Using rapid discrete-molecular-dynamics simulations, we examined the binding of graphene and graphene oxide with peptides, fatty acids, and ...
Radic, Slaven +6 more
openaire +4 more sources
Competitive interactions of ligands and macromolecular crowders with maltose binding protein. [PDF]
PLoS ONE, 2013 Cellular signaling involves a cascade of recognition events occurring in a complex environment with high concentrations of proteins, polysaccharides, and other macromolecules.
Andrew C Miklos +2 more
doaj +1 more source
Competitive Binding of HIF-1α and CITED2 to the TAZ1 Domain of CBP from Molecular Simulations
, 2020 Many intrinsically disordered proteins (IDPs) are involved in complex signalling networks inside the cell. Their particular binding modes elicit different types of responses and subtle regulation of biological responses.
David, De Sancho +3 more
core +1 more source
The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies [PDF]
, 2013 SUMMARY Binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the Leishmania life cycle in the vector. Among Leishmania surface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored ...
Jecna, Lucie +13 more
core +1 more source