Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding
Bio-Protocol, 2014 Lipopolysaccharide is the major constituent of the outer membrane of gram-negative bacteria and, once released from the bacterial surface into the bloodstream, is a potent activator of the host immune system, which can lead to septic shock.
Victoria Martínez-Sernández +1 more
doaj +1 more source
Chemokine Cooperativity Is Caused by Competitive Glycosaminoglycan Binding [PDF]
The Journal of Immunology, 2014 Abstract Chemokines comprise a family of secreted proteins that activate G protein–coupled chemokine receptors and thereby control the migration of leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by the binding of chemokines to membrane-tethered ...
Verkaar, F. +14 more
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Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70
Molecules, 2022 Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s
Suzanne O’Connor +10 more
doaj +1 more source
Competitive Binding of Natural Amphiphiles with Graphene Derivatives [PDF]
Scientific Reports, 2013 Understanding the transformation of graphene derivatives by natural amphiphiles is essential for elucidating the biological and environmental implications of this emerging class of engineered nanomaterials. Using rapid discrete-molecular-dynamics simulations, we examined the binding of graphene and graphene oxide with peptides, fatty acids, and ...
Radic, Slaven +6 more
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High glucose disrupts oligosaccharide recognition function via competitive inhibition : a potential mechanism for immune dysregulation in diabetes mellitus [PDF]
, 2011 Diabetic complications include infection and cardiovascular disease. Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin.
Bee K. Tan +19 more
core +1 more source
Analysis of a Mathematical Model of Real-Time Competitive Binding on a Microarray [PDF]
, 2022 A mathematical model of competitive binding on a microarray in real-time yields a planar system of nonlinear ordinary differential equations. This model can be used to explore dimensionless formulation, linear approximation, and reduction.
Lynch, Frank H, Frank Lynch
core +1 more source
Competitive Binding of Parkinsonian‐inducing Neurotoxins to Neuromelanin [PDF]
, 2016 Competitive Binding of Parkinsonian‐inducing Neurotoxins to NeuromelaninHaining, Robert (faculty ...
Hernandez, Aubrey
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Cooperation, Competition, and Ties That Bind
The Canadian Journal of Hospital Pharmacy, 2019 -
openaire +3 more sources
Molecular Additives as Competitive Binding Agents to Control Supramolecular-Driven Nanoparticle Assembly [PDF]
ACS Nanoscience AuRebecca L. Li +3 more
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Competitive binding curves of characteristic ligands to recombinant HoblOBP4.
, 2013 The chemical structures of the ligands are shown on the right. (A) Competitive binding curves of aliphatic alcohols and aldehydes with six carbon numbers. (B) Competitive binding curves of different structural on terpenoids with ten carbon numbers.
Li Guan (115858) +5 more
core +1 more source