Results 21 to 30 of about 2,770,096 (297)

Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking

Heliyon, 2023
P2X purinoceptor 4 (P2X4) is an ATP-gated ion channel receptor with diverse neurophysiological functions, and P2X4 modulators hold promise as potential therapeutics for neuropathic pain, neuroinflammation, and neurodegenerative diseases.
Tess Puopolo, Ang Cai, Chang Liu, Hang Ma, Navindra P. Seeram   +4 more
doaj   +1 more source

Is styrene competitive for dopamine receptor binding?

Biomolecular Concepts, 2022
The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations.
De Santis Emiliano, Minicozzi Velia, Rossi Giancarlo, Stellato Francesco, Morante Silvia   +4 more
doaj   +1 more source

In Vitro Evaluation of Fluorescence Glucose Biosensor Response

Sensors, 2014
Rapid, accurate, and minimally-invasive glucose biosensors based on Förster Resonance Energy Transfer (FRET) for glucose measurement have the potential to enhance diabetes control.
Mamdouh Aloraefy, T. Joshua Pfefer, Jessica C. Ramella-Roman, Kim E. Sapsford   +3 more
doaj   +1 more source

Integrating binding and expression data to predict transcription factors combined function

BMC Genomics, 2020
Background Transcription factor binding to the regulatory region of a gene induces or represses its gene expression. Transcription factors share their binding sites with other factors, co-factors and/or DNA-binding proteins. These proteins form complexes
Mahmoud Ahmed, Do Sik Min, Deok Ryong Kim   +2 more
doaj   +1 more source

Discrimination of Oviposition Deterrent Volatile β-Ionone by Odorant-Binding Proteins 1 and 4 in the Whitefly Bemisia tabaci

Biomolecules, 2019
: The whitefly, Bemisia tabaci, is an important invasive economic pest of agricultural crops worldwide. β-ionone has a significant oviposition repellent effect against B. tabaci, but the olfactory molecular mechanism of this insect for recognizing &#
Fengqi Li, Du Li, Youssef Dewer, Cheng Qu, Zhen Yang, Jiahui Tian, Chen Luo   +6 more
doaj   +1 more source

Computational fragment-based binding site identification by ligand competitive saturation. [PDF]

PLoS Computational Biology, 2009
Fragment-based drug discovery using NMR and x-ray crystallographic methods has proven utility but also non-trivial time, materials, and labor costs.
Olgun Guvench, Alexander D MacKerell
doaj   +1 more source

nordenfeltLab/competitive-polyclonal-antibody-binding-model: Initial release

, 2020
competitive-polyclonal-antibody-binding ...
Vibha Kumra Ahnlide
core   +1 more source

Molecular Mechanisms Underlying Inhibitory Binding of Alkylimidazolium Ionic Liquids to Laccase

Molecules, 2017
Water-miscible alkylimidazolium ionic liquids (ILs) are “green” co-solvents for laccase catalysis, but generally inhibit enzyme activity. Here, we present novel insights into inhibition mechanisms by a combination of enzyme kinetics analysis and ...
Jianliang Sun, Hao Liu, Wenping Yang, Shicheng Chen, Shiyu Fu   +4 more
doaj   +1 more source

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang, Hooper, Tony, Pickett, John, Field, Lin   +23 more
core   +1 more source

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy. [PDF]

, 2022
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation.
Wang, Yingjie, Walker, Caitlin, Kim, Jonggul, De Simone, Alfonso, Vendruscolo, Michele, Olivieri, Cristina, Camilloni, Carlo, Veglia, Gianluigi, Kim J., Taylor, Susan S, Carlo Camilloni, David A. Bernlohr, Taylor S. S., Jonggul Kim, Wang Y., Bernlohr D. A., Alfonso De Simone, Walker C., Bernlohr, David A, Camilloni C., Vendruscolo M., Li G. C., Olivieri C., Geoffrey C. Li, Caitlin Walker, De Simone A., Veglia G., Yingjie Wang, Manu V. S., Susan S. Taylor, Gianluigi Veglia, Cristina Olivieri, Li, Geoffrey C, V S, Manu, Michele Vendruscolo, Manu V.S.   +35 more
core   +3 more sources