Results 41 to 50 of about 285,043 (352)
Cooperation, Competition, and Ties That Bind
The Canadian Journal of Hospital Pharmacy, 2019 -
openaire +3 more sources
Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores. [PDF]
PLoS ONE, 2010 In an analytical model channel transport is analyzed as a function of key parameters, determining efficiency and selectivity of particle transport in a competitive molecular environment.
Wolfgang R Bauer, Walter Nadler
doaj +1 more source
IUCrJ, 2021 Death-associated protein kinase 1 (DAPK1) is a large multidomain protein with an N-terminal serine/threonine protein kinase domain. DAPK1 is considered to be a promising molecular target for the treatment of Alzheimer's disease (AD). In the present study,
Takeshi Yokoyama +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Frontiers in Chemistry, 2019 The primary objective of early drug development is to identify hits and leads for a target of interest. To achieve this aim, rapid, and reliable screening techniques for a huge number of compounds are needed.
Jürgen Gabriel +2 more
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Frontiers in Pharmacology, 2022 Our group has developed and experimentally validated a strategy to increase antibody penetration in solid tumors through transient inhibition of antibody-antigen binding. In prior work, we demonstrated that 1HE, an anti-trastuzumab single domain antibody
Brandon M. Bordeau +4 more
doaj +1 more source
Competitive binding curves of characteristic ligands to recombinant HoblOBP4.
, 2013 The chemical structures of the ligands are shown on the right. (A) Competitive binding curves of aliphatic alcohols and aldehydes with six carbon numbers. (B) Competitive binding curves of different structural on terpenoids with ten carbon numbers.
Li Guan (115858) +5 more
core +1 more source
Inflation, Prices, and Information in Competitive Search [PDF]
, 2005 We study the effects of inflation in a competitive search model where each buyer’s utility is private information, and money is essential. The equilibrium is efficient at the Friedman rule, but inflation creates an inefficiency in the terms of trade ...
Belén Jerez +3 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Establishment of competitive binding assay to detect and differentiate hepatitis E virus infection
Annals of Hepatology, 2019 Introduction and Objectives: This study was undertaken to demonstrate a promising approach for detection and differentiation the serum immunoglobulin G (IgG) against hepatitis E virus (anti-HEV IgG) using a competitive binding assay established with ...
Jiyue Wen, Weizhuo Lu, Jihong Meng
doaj +1 more source