Results 61 to 70 of about 285,043 (352)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Competitive binding of MOP to CquiOBP1.

, 2013
Fluorescence emission spectra of CquiOBP1 alone (15 µg/ml; black), in the presence of NPN (2 µl, 3.2 mM; light red), and after titrating with increasing amounts of MOP (1–3 µl, 3.2 mM; green, blue, and dark red lines).
Rosângela M. R. Barbosa (376861), Zainulabeuddin Syed (315193), Tania I. Morgan (376864), Angela M. Chen (376863), Nicolas Latte (376862), Walter S. Leal (104796), Yuko Ishida (104789), Wei Xu (28953), André Furtado (376865), Anthony J. Cornel (137682)   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identification and Functional Analysis of SlitOBP11 From Spodoptera litura

Frontiers in Physiology, 2021
Odorant binding proteins (OBPs) play a key role in the olfactory recognition of insects, whose functions have been extensively studied in adult insects but rarely in larvae.
Jiaojiao Luo, Jiaojiao Luo, Jiaojiao Luo, Zan Zhang, Zan Zhang, Zan Zhang, Dongzhen Li, Jie Liu, Jie Liu, Jie Liu, Kun Li, Kun Li, Kun Li, Xiao Sun, Lin He, Lin He, Lin He   +16 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The pH-dependence of the binding of competitive inhibitors to pepsin [PDF]

Biochemical Journal, 1969
1. The pH-dependence of the binding to pepsin of four dipeptide competitive inhibitors is reported. Values of Ki obtained from equilibrium-dialysis experiments agree closely with those from kinetic measurements. 2. The binding of uncharged N-acyl-dipeptide amides to pepsin is essentially independent of pH from 0·2 to 5·8.
J R, Knowles, H, Sharp, P, Greenwell
openaire   +2 more sources

A competitive binding between O2 and epoxy with carbon nanotubes

AIP Advances, 2017
Simulation and observation reveal a competitive binding between O2 and epoxy with carbon nanotubes. Air absorption limits tube-polymer interacting coverage and weakens the van der Waals forces.
Hsin-Jung Tsai, Yu-Ying Su, Chao-Chi Tseng, Wen-Kuang Hsu   +3 more
doaj   +1 more source

Interactions Between Sirolimus and Anti-Inflammatory Drugs: Competitive Binding for Human Serum Albumin [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: The aim of the present study was investigating the effects of three anti-inflammatory drugs, on Sirolimus protein biding. The binding site of Sirolimus on human serum albumin (HSA) was also determined.
Arash Khodaei, Soheila Bolandnazar, Hadi Valizadeh, Leila Hasani, Parvin Zakeri-Milani   +4 more
doaj   +1 more source

Competitive protein binding assay for methotrexate

, 1975
A competitive protein binding assay has been developed for methotrexate based on the tight binding of this drug to Lactobacillus casei dihydrofolate reductase (= tetrahydrofolate dehydrogenase; 5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase; EC 1.5.1.3).
Myers, C E, Lippman, M E, Chabner, B A, Elliot, H M   +3 more
core   +1 more source