Results 61 to 70 of about 2,617,399 (295)

Mapping of the ligand-binding site on the b ' domain of human PDI: interaction with peptide ligands and the x-linker region [PDF]

, 2009
PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four thioredoxin-like domains, of which two contain redox-active catalytic sites (a and a'), and two ...
Freedman, R. B., Howard, M., Williamson, Richard A., Howard, Mark J., Wallis, A. Katrine, Ruddock, Lloyd W., Sidhu, A., Wallis, A., Williamson, R., Byrne, Lee J., Freedman, Robert B., Ruddock, L., Sidhu, Ateesh, Wallis, Anne Katrine, Byrne, L., Freedman, R.   +15 more
core   +1 more source

Assessment of binding interaction to salmon sperm DNA of two antiviral agents and ecofriendly nanoparticles: comprehensive spectroscopic study

BMC Chemistry, 2023
The direct binding of antiviral agents; Daclatasvir and valacyclovir and green synthesized nanoparticles to salmon sperm DNA have been assessed in a comparative study.
Ahmed Faried Abdel Hakiem, Ahmed Mohsen Kamal El-Sagheir, Mohammed E. Draz, Niveen A. Mohamed, Ahmed Safwat Aboraia   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Real Power Loss Reduction by Enhanced Imperialist Competitive Algorithm [PDF]

, 2017
In this paper, an Enhanced Imperialist Competitive (EIC) Algorithm is proposed for solving reactive power problem. Imperialist Competitive Algorithm (ICA) which was recently introduced has shown its decent performance in optimization problems.
Kanagasabai, Lenin
core   +1 more source

Unraveling competitive protein interactions: A critical step toward improved production and therapeutics

Journal of Advanced Research
Background: Competitive protein binding plays a pivotal role in regulating biological processes by influencing how proteins interact with shared ligands or binding sites.
Yuan Tian, Xiao-Yue Zhang, Mehtab Muhammad Aslam, Muhammad Yahya Tahir, Meisam Zargar, Jingjing Huang, Fu-Yuan Zhu, MoXian Chen, Li-sheng Wan, Ying-Gao Liu   +9 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A competitive binding between O2 and epoxy with carbon nanotubes

AIP Advances, 2017
Simulation and observation reveal a competitive binding between O2 and epoxy with carbon nanotubes. Air absorption limits tube-polymer interacting coverage and weakens the van der Waals forces.
Hsin-Jung Tsai, Yu-Ying Su, Chao-Chi Tseng, Wen-Kuang Hsu   +3 more
doaj   +1 more source