Results 81 to 90 of about 2,770,096 (297)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Competitive binding assays of the Cry8 toxin and toxin-DNA complex using the BBMVs from the target larvae.

, 2013
A. Competitive binding of the Cry8Ea1 toxin and Cry8Ea1 toxin-DNA complex with the BBMVs of H. parallela larvae. B. Competitive binding of the Cry8Ca2 toxin and Cry8Ca2 toxin-DNA complex with the BBMVs of A. corpulenta larvae.
Bingjie Ai (492597), Shuyuan Guo (307629), Feng Li (30515), Dongmei Feng (492598), Jie Li (15030)   +4 more
core   +1 more source

Competitive binding of chlorophyllin and proflavine to DNA

Біофізичний вісник, 2016
The effect of chlorophyllin (Chln) on the DNA-proflavine (Pf) interactions has been investigated by spectrophotometry. The absorption spectra were recorded at different DNA-to-ligand molar ratios.
А. А. Герус, Н. А. Гладковская, Е. Г. Березняк, Е. В. Духопельников   +3 more
doaj  

The key to 2,6-dichloro-1,4-benzoquinone reproductive toxicity and green tea detoxification: Covalent binding and competitive binding

Ecotoxicology and Environmental Safety
Halobenzoquinones (HBQs) are ubiquitous disinfection by-products (DBPs) in chlorinated drinking water with various health risks including reproductive toxicity, while the potential mechanisms are still unclear.
Meixian Liu, Zhiyuan Ning, Yong Cheng, Zhiyuan Zheng, Xiaoxue Yang, Ting Zheng, Na Li, Jian-Lin Wu   +7 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Study of competitive binding of enantiomers to protein by affinity capillary electrochromatography

, 2002
Affinity capillary electrochromatography (CEC) with zonal elution method was used to probe the competitive interactions of enantiomers with protein. In this approach, a known concentration of a competing agent is continuously applied to a CEC column with
Lei, ZD, Zou, HF, Liu, Z, Wu, RN, Ni, JY, Ye, ML   +5 more
core  

Competitive binding of candidate ligands with 1-NPN and recombinant FoccCSP protein.

, 2015
Competitive binding of candidate ligands with 1-NPN and recombinant FoccCSP protein.
Zhong-Ren Lei (688118), Zhi-Ke Zhang (688117)   +1 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II

Pharmaceuticals
Background/Objectives: DPP4 is an enzyme with multiple natural substrates and probable involvement in various mechanisms. It constitutes a drug target for the treatment of diabetes II, although, also related to other disorders.
Dionysia Amanatidou, Phaedra Eleftheriou, Anthi Petrou, Athina Geronikaki, Theodoros Lialiaris   +4 more
doaj   +1 more source

Studies on the Binding of Carboxypeptidase A and Several Competitive Inhibitors

Journal of Biological Chemistry, 1962
Several spectral changes have been reported to be related to changes in bonding or other factors in the environment of the side chains of aromatic amino acid residues (l-lo). It would then be expected that on addition of a competitive inhibitor to an enzyme solution, a change in the spectrum of the enzyme could be observed, if aromatic amino acid ...
H, FUJIOKA, K, IMAHORI
openaire   +2 more sources