Results 101 to 110 of about 2,770,096 (297)
Spatial feature binding and learning in competitive neural layer architectures
, 2000 Wersing H. Spatial feature binding and learning in competitive neural layer architectures.
Wersing, Heiko
core
, 1997 The human osteocalcin gene is transcriptionally repressed by glucocorticoids. A specific binding element for the glucocorticoid receptor (GR) overlapping the TATA box of the human osteocalcin promoter has previously been identified. In the present study,
Gustafsson, JA +2 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Competitive binding of monoclonal antibodies.
, 2012 Each monoclonal antibody was labeled with horseradish peroxidase (HRPO). The ability of a large excess of each unlabeled antibody to inhibit the binding of HRPO MAbs was measured.
Gerald R. Nakamura (158427) +4 more
core +1 more source
Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics [PDF]
, 2014 EB1 is a conserved protein that plays a central role in regulating microtubule dynamics and organisation. It binds directly to microtubule plus ends and recruits other plus end localising proteins.
Warbrick, Emma +2 more
core +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Dual enzyme labels for simultaneous heterogeneous enzyme-linked competitive binding assays
, 1994 The use of two enzyme labels in a dual analyte simultaneous heterogeneous enzyme-linked competitive binding assay is examined. Reaction conditions for monitoring glucose-6-phosphate dehydrogenase (G6PDH) and [beta]-galactosidase ([beta]-gal) activities ...
Buckwalter, Jeanette M. +2 more
core +1 more source
Combined Selection and Binding for Competitive Resource Environments [PDF]
, 2005 A critical technology for Grid computing is the ability to describe, select, and bind appropriate resources for synchronous use by applications.
Kee, Yang-Suk +2 more
core +1 more source