Results 11 to 20 of about 285,043 (352)

Competitive binding assay.

, 2014
Competitive binding assay on wt-ERαLBD (blue squares), M421F-ERαLBD (red circles) and M421I-ERαLBD (green triangles) with six different compounds: 17β-estradiol (panel A), 17α-ethinylestradiol (panel B), bisphenol-A (panel C), tamoxifen (panel D), 4 ...
Valentina Elisabetta Viviana Ferrero (606399), Alessandro Chiadò (606400), Teresa Lettieri (13593), Luca Simonelli (279931), Luca Varani (279935), Mattia Pedotti (279932), Luigi Calzolai (279934)   +6 more
core   +2 more sources

Competitive dCas9 binding as a mechanism for transcriptional control [PDF]

Molecular Systems Biology, 2021
Catalytically dead Cas9 (dCas9) is a programmable transcription factor that can be targeted to promoters through the design of small guide RNAs (sgRNAs), where it can function as an activator or repressor.
Daniel A Anderson, Christopher A Voigt
doaj   +3 more sources

IGF uptake with competitive binding in articular cartilege [PDF]

Journal of Biological Systems, 2008
Experiments on the transport of radiolabeled Insulin-like Growth Factors (IGF-I and -II) into bovine articular cartilage show differential uptake depending on the relative proportion of IGF-I and -II.
Pivonka, P., Smith, D. W., Grodzinsky, A. J., Zhang, L., Gardiner, B. S., Smith, D.W., Grodzinsky, A.J., Gardiner, B.S.   +7 more
core   +3 more sources

Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data [PDF]

PeerJ, 2023
Transcription factor binding to a gene regulatory region induces or represses its expression. Binding and expression target analysis (BETA) integrates the binding and gene expression data to predict this function.
Mahmoud Ahmed, Deok Ryong Kim
doaj   +2 more sources

A Polarity-Sensitive Far-Red Fluorescent Probe for Glucose Sensing through Skin

Biosensors, 2023
The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important to continuously track the glucose level to provide better management of the disease.
Lydia Colvin, Dandan Tu, Darin Dunlap, Alberto Rios, Gerard Coté   +4 more
doaj   +1 more source

A Novel Strategy for Enhanced Sequestration of Protein-Bound Uremic Toxins Using Smart Hybrid Membranes

Journal of Functional Biomaterials, 2023
Currently available hemodialysis (HD) membranes are unable to safely remove protein-bound uremic toxins (PBUTs), especially those bonded to human serum albumin (HSA).
Madalena Lopes, Rita F. Pires, Mónica Faria, Vasco D. B. Bonifácio   +3 more
doaj   +1 more source

Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding

mAbs, 2021
Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins.
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Arnold McAuley, Margaret S. Ricci, Pavel V. Bondarenko   +5 more
doaj   +1 more source

Experimental and Computational Investigation on the Interaction of Anticancer Drug Gemcitabine with Human Plasma Protein: Effect of Copresence of Ibuprofen on the Binding

Molecules, 2022
The interaction of common anticancer drug gemcitabine with human serum albumin (HSA) has been studied in detail. The effect of an omnipresent nonsteroidal anti-inflammatory drug ibuprofen was also seen on the binding of HSA and gemcitabine.
Mohd Sajid Ali, Hamad A. Al-Lohedan
doaj   +1 more source

Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking

Heliyon, 2023
P2X purinoceptor 4 (P2X4) is an ATP-gated ion channel receptor with diverse neurophysiological functions, and P2X4 modulators hold promise as potential therapeutics for neuropathic pain, neuroinflammation, and neurodegenerative diseases.
Tess Puopolo, Ang Cai, Chang Liu, Hang Ma, Navindra P. Seeram   +4 more
doaj   +1 more source

Competition between LIM-binding domains [PDF]

Biochemical Society Transactions, 2008
LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline, Bhati, Mugdha, Craig, Vanessa J, Deane, Janet E, Jeffries, Cy, Lee, Christopher, Nancarrow, Amy L, Ryan, Daniel, Sunde, Margaret   +8 more
openaire   +4 more sources