Results 31 to 40 of about 4,262,535 (256)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Evolution of innate behavioral strategies through competitive population dynamics.

open access: yesPLoS Computational Biology, 2022
Many organism behaviors are innate or instinctual and have been "hard-coded" through evolution. Current approaches to understanding these behaviors model evolution as an optimization problem in which the traits of organisms are assumed to optimize an ...
Tong Liang, Braden A W Brinkman
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Climate Change Sustainability: From Bargaining to Cooperative Balanced Approach

open access: yesGames, 2021
This work aims to provide different perspectives on the relationships between cooperative game theory and the research field concerning climate change dynamics.
Tiziana Ciano   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The Container Market in Baltic Ports: Market Share Development and Trend Forecasting

open access: yesBig Data and Cognitive Computing
This study examines the evolution of container throughput and competitive market-share dynamics in the three principal Baltic container ports—Klaipeda, Riga, and Tallinn—during the period 2005–2024 and provides baseline forecasts to 2030.
Diana Šateikienė, Jurga Kučinskienė
doaj   +1 more source

Rating competitive dynamics under the influence of innovation [PDF]

open access: yesMarketing i Menedžment Innovacij, 2013
The aim of the article. Competitiveness of enterprises is one of the most important categories of market economy and describes a possibility and efficiency of enterprise adaptation to the conditions of competitive environment.Complex problems of ...
A.O. Kolomytseva, L.A. Golovan
doaj  

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

FORMATION OF COMPETITIVE ADVANTAGES OF ENTERPRISES IN TERMS OF GLOBALIZATION: COMPETITIVE DYNAMICS AND AN INTELLECTUAL COMPONENT [PDF]

open access: yesBaltic Journal of Economic Studies, 2017
The purpose of the article is to investigate the current state of scientific thought in relation to the formation of intellectual capital of an enterprise in the innovation process, achievement by the enterprise of corresponding competitive advantages ...
Oleg Tarasenko   +2 more
doaj   +1 more source

Proceedings of Pedestrian and Evacuation Dynamics 2016

open access: yes, 2016
n a recent series of papers, we proposed a mathematical model for the dynamics of a group of interacting pedestrians. The model is based on a non-Newtonian potential, that accounts for the need of pedestrians to keep both their interacting partner and ...
Takayuki Kanda   +2 more
core   +1 more source

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