Results 71 to 80 of about 1,026,236 (294)

Coupled Replicator Equations for the Dynamics of Learning in Multiagent Systems

, 2002
Starting with a group of reinforcement-learning agents we derive coupled replicator equations that describe the dynamics of collective learning in multiagent systems.
B. Kerr, Cf.P. Schuster, E. van Nimwegen, H. Yoshida, J. Hofbauer, J.P. Crutchfield, James P. Crutchfield, M. Marsili, M. Taiji, O.E. Rossler, P. Taylor, P. Taylor, T. Borgers, T. Chawanya, Y. Sato, Yuzuru Sato   +15 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Maternal effects and the outcome of interspecific competition

Ecology and Evolution, 2021
Maternal environmental effects create lagged population responses to past environments. Although they are ubiquitous and vary in expression across taxa, it remains unclear if and how their presence alters competitive interactions in ecological ...
Benjamin Van Allen, Natalie Jones, Benjamin Gilbert, Kelly Carscadden, Rachel Germain   +4 more
doaj   +1 more source

Quotas Under Dynamic Bertrand Competition [PDF]

SSRN Electronic Journal, 2008
We present a new model of dynamic Bertrand competition, where a quota is treated as an intertemporal constraint rather than as a capacity constraint as is common in the literature. The firm under a quota then can still vary the rates of exports over time provided that its total sales within the period do not exceed the quota.
Miyagiwa, Kaz, Ohno, Yuka
openaire   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Analytical and mathematical instruments of the competitive dynamic diagnostics in the retail dealing [PDF]

Marketing i Menedžment Innovacij, 2014
The aim of the article. The purpose of the article is to form authoring management concept to competitive dynamics retailers; to improve analytical and diagnostic tools for researching of the level of competitive retailers dynamics based on statistical ...
Zagornaya Tetiana Olehivna
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A Mathematical Analysis of Competitive Dynamics and Aggressive Treatment in the Evolution of Drug Resistance in Malaria Parasites

Mathematics
Experimental evidence supports the counterintuitive notion that rapid eradication of pathogens within a host, infected with both drug-sensitive and -resistant malaria parasites, can actually accelerate the evolution of drug-resistant pathogens.
Tianqi Song, Yishi Wang, Yang Li, Guoliang Fan   +3 more
doaj   +1 more source

Competitive Marketing Strategy

Maketingu Janaru, 2019
Traditionally, marketing research has taken the view that competition should be avoided. However, given today’s environment, which is characterized by intense and rapid competitive moves, there is a need for a new marketing research approach that begins ...
Sena Nakamura
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source