Results 41 to 50 of about 318,502 (328)

A GRASP model in network design for two-stage supply chain [PDF]

Management Science Letters, 2011
We consider a capacitated facility location problem (CFLP) which contains a production facility and distribution centers (DCs) supplying retailers' demand.
Hassan Javanshir, Mahdis Haghighi Ghashti   +1 more
doaj  

A human learning optimization algorithm with competitive and cooperative learning

Complex & Intelligent Systems, 2022
Human learning optimization (HLO) is a simple yet powerful metaheuristic developed based on a simplified human learning model. Competition and cooperation, as two basic modes of social cognition, can motivate individuals to learn more efficiently and ...
JiaoJie Du, Ling Wang, Minrui Fei, Muhammad Ilyas Menhas   +3 more
doaj   +1 more source

Regional competition for the location of new facilities [PDF]

The Annals of Regional Science, 2002
A model of interregional competition for the location of new facilities is analyzed as a differential game. Two regions try to enhance their attraction by making concessions to a location decision maker in order to raise the probability that a new facility will be located in a specific region.
openaire   +3 more sources

A Location Routing Problem with Time Windows Consideration: A Metaheuristics Approach

Applied Sciences, 2023
A substantial distribution system is achievable to attain through the simultaneous design of the location facility and route generation. This problem is generally called a location routing problem (LRP), where both strategic decision and operational ...
Meilinda Fitriani Nur Maghfiroh, Vincent F. Yu, Anak Agung Ngurah Perwira Redi, Bayu Nur Abdallah   +3 more
doaj   +1 more source

The theory of international business: the role of economic models [PDF]

, 2018
This paper reviews the scope for economic modelling in international business studies. It argues for multi-level theory based on classic internalisation theory.
AA Alchian, B Klein, C Kindleberger, C Vaitsos, FR Warren-Boulton, GDA MacDougall, H Demsetz, J-C Spender, JH Dunning, JH Dunning, KJ Arrow, M Casson, M Casson, M Casson, M Casson, M Casson, M Casson, M Casson, Mark Casson, MC Kemp, ME Porter, MS Morgan, OE Williamson, OE Williamson, PJ Buckley, PJ Buckley, PJ Buckley, RH Coase, SH Hymer, SNS Cheung   +29 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Efficiency of a multi-objective imperialist competitive algorithm: A bi-objective location-routing-inventory problem with probabilistic routes [PDF]

Journal of Artificial Intelligence and Data Mining, 2014
An integrated model considers all parameters and elements of different deficiencies in one problem. This paper presents a new integrated model of a supply chain that simultaneously considers facility location, vehicle routing and inventory control ...
N. Nekooghadirli, R. Tavakkoli-Moghaddam, V.R. Ghezavati   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Solving the competitive facility location problem considering the reactions of competitor with a hybrid algorithm including Tabu Search and exact method

Journal of Industrial Engineering International, 2017
In this paper, a leader–follower competitive facility location problem considering the reactions of the competitors is studied. A model for locating new facilities and determining levels of quality for the facilities of the leader firm is proposed ...
Jafar Bagherinejad, Azar Niknam
doaj   +1 more source