Results 51 to 60 of about 318,502 (328)

Location and design of a competitive facility for profit maximisation [PDF]

, 2004
A single facility has to be located in competition with fixed existing facilities of similar type. Demand is supposed to be concentrated at a finite number of points, and consumers patronise the facility to which they are attracted most.
Carrizosa Priego, Emilio José, Plastria, Frank   +1 more
core  

Exact approaches for competitive facility location with discrete attractiveness [PDF]

Optimization Letters, 2020
We study a variant of the competitive facility location problem, in which a company is to locate new facilities in a market where competitor's facilities already exist. We consider the scenario where only a limited number of possible attractiveness levels is available, and the company has to select exactly one level for each open facility.
Yun Hui Lin, Qingyun Tian
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Online Algorithmic Study of Facility Location Problems: A Survey

IEEE Access
Facility Location problems are one of the most prominent optimization problems in computer science, operations research, and combinatorial optimization. Their simple yet intrinsic structure has led to their widespread application in diverse fields, such ...
Christine Markarian
doaj   +1 more source

Trends in the development of additional services to create competitive advantages of a hotel

Економіка, управління та адміністрування, 2020
Hotel complexes offer a large number of services that are aimed at satisfying the specific desires of consumers. Today, the number of consumers who are not satisfied with the monotony of standard hotels is steadily increasing, and when planning a holiday
A.O. Chagaida
doaj   +1 more source

The Assessment and Comparison of a Genetic Algorithm, Simulated Annealing and Cuckoo Optimization Algorithm for Optimization of the Facility Location under Competitive Conditions (Case Study: Banks) [PDF]

مجله مدل سازی در مهندسی, 2017
This paper determines the location of bank branches under competitive conditions with different attractive conditions. Finding an optimum location of branches depends on many factors and these problems are known as NP-hard problems.
Farshad Hakim pour, Siamak Talat Ahary, Abolfazl Ranjbar   +2 more
doaj   +1 more source

The Incremental Cooperative Design of Preventive Healthcare Networks [PDF]

, 2017
This document is the Accepted Manuscript version of the following article: Soheil Davari, 'The incremental cooperative design of preventive healthcare networks', Annals of Operations Research, first published online 27 June 2017. Under embargo.
A Ahmadi-Javid, A Basar, A Ghaderi, AK Vatsa, AR McKendall Jr, B Rottkemper, C Duhamel, DG Kim, DH Lee, DR Bell, G Damiani, G Wei, H Karimi, HI Meissner, HJ Ko, HK Rajagopalan, I Correia, I Correia, I Muler, JB Fox, JC Benneyan, JE Beasley, JE Torres-Soto, JT Pastor, K Haase, L Zhen, M Albareda-Sambola, M Albareda-Sambola, M Albareda-Sambola, M Elbek, M Gen, M Nakanishi, M Ndiaye, M Sato, M Varkevisser, MHF Zarandi, N Markovic, N Mladenović, O Berman, R Haynes, R Manzini, R Santos, S Belhaiza, S Davari, S Davari, S Davari, S Gelareh, S Mahar, SH Chung, SL Hakimi, Soheil Davari, SS Syam, T Drezner, T Drezner, V Schmid, V Schmid, V Verter, W Yi, WJ Reilly, XF Wang, Y Hinojosa, Y Sha, Y Zhang, Y Zhang, Y Zhang, É Gourdin   +65 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Reallocating Multiple Facilities on the Line

, 2019
We study the multistage $K$-facility reallocation problem on the real line, where we maintain $K$ facility locations over $T$ stages, based on the stage-dependent locations of $n$ agents. Each agent is connected to the nearest facility at each stage, and
Fotakis, Dimitris, Kavouras, Loukas, Kostopanagiotis, Panagiotis, Lazos, Philip, Skoulakis, Stratis, Zarifis, Nikolas   +5 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source