Results 111 to 120 of about 145,979 (303)
Understanding the Future Competitive Advantages of the Construction Industry
BuildingsTechnological changes (such as Construction 4.0) in an organization cause the workforce to exhibit resistance to change, job redundancy, etc. Geographical location will no longer provide a competitive advantage, but resources will be the source of ...
Fortune Aigbe +3 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Firm Heterogeneity and Location Choice [PDF]
Heterogeneity in firm productivity affects the location patterns of firm and agglomeration. Here we provide an economic geography model, involving forward and backward linkages driven by the migration of a footloose entrepreneur (capital owner) with ...
Toshihiro Okubo
core
Competitive and voting location.
, 2009 We consider competitive location problems where two competing providers place their facilities sequentially and users can decide between the competitors. We assume that both competitors act non-cooperatively and aim at maximizing their own benefits. We investigate the complexity and approximability of such problems on graphs, in particular on simple ...
openaire +2 more sources
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
A primal-dual algorithm for online non-uniform facility location
, 2007 In the online version of Facility Location, the demand points arrive one at a time and must be irrevocably assigned to an open facility upon arrival. The objective is to minimize the sum of facility and assignment costs. We present a simple deterministic
Fotakis, Dimitris, Fotakis, D
core +1 more source
Applied SciencesThis study aimed to (1) analyse home advantage (HA) and home winning percentage (HW), and (2) examine the impact of team level on HA and HW across major European men’s handball leagues from 2021–2022 to 2024–2025.
Moisés Marquina Nieto +5 more
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
A Location Game On Disjoint Circles [PDF]
Two players are endowed with resources for setting up N locations on K identical circles, with N > K>= 1. The players alternately choose these locations (possibly in batches of more than one in each round) in order to secure the area closer to their ...
Jaideep Roy +2 more
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