Results 81 to 90 of about 145,979 (303)

Competitive Location Modeling with a Rank Proportional Allocation

open access: yes, 2011
Competitive location modeling deals with a strategic spatial decision which seeks to identify optimal locations for new facilities among existing competing facilities.
Gunhak Lee, Morton E O'Kelly
core   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Incorporating waiting time in competitive location models: Formulations and heuristics [PDF]

open access: yes
In this paper we propose a metaheuristic to solve a new version of the Maximum Capture Problem. In the original MCP, market capture is obtained by lower traveling distances or lower traveling time, in this new version not only the traveling time but also
Francisco Silva, Daniel Serra
core  

A Localização Geográfica como Recurso Organizacional: Utilização de Sistemas Especialistas para Subsidiar a Tomada de Decisão Locacional do Setor Bancário [PDF]

open access: yesRAC: Revista de Administração Contemporânea, 2011
The location of a business site is a material resource and, along with its financial and technological resources, may provide a company with a distinguished position in comparison with its competitors.
Ana Maria dos Santos Carnasciali   +1 more
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Multi-Size Facility Allocation Under Competition: A Model with Competitive Decay and Reinforcement Learning-Enhanced Genetic Algorithm

open access: yesISPRS International Journal of Geo-Information
In modern urban planning, the problem of bank location requires not only considering geographical factors but also integrating competitive elements to optimize resource allocation and enhance market competitiveness.
Zixuan Zhao   +3 more
doaj   +1 more source

Labour implementation and efficiency of the foodstuffs wholesales

open access: yesAgricultural Economics (AGRICECON), 2002
The analysis is made in the set of the selected foodstuffs wholesales in the Slovak Republic and shows their differences from the viewpoint of the size (sale place 15 m2-1 300 m2 , storage space 106 m2-6 500 m2 ), number of workers (1-81) and yearly ...
M. Vicen, I. Ubrežiová
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Location models in the public sector [PDF]

open access: yes
The past four decades have witnessed an explosive growth in the field of networkbased facility location modeling. This is not at all surprising since location policy is one of the most profitable areas of applied systems analysis in regional science and ...
Daniel Serra, Vladimir Marianov
core  

A multi-objective evolutionary algorithm for finding efficient solutions to a competitive facility location problem

open access: yes, 2012
This chapter investigates the performance of several Multi-Objective Evolutionary Algorithms (MOEAs) in discovering solutions to the Competitive Facility Location (CFL) problem and a sensitivity analysis of the solutions related to input parameters.
Janssens, Gerrit K.   +2 more
core   +1 more source

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