Results 71 to 80 of about 1,151,001 (290)
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
The reentry hypothesis: The putative interaction of the frontal eye field, ventrolateral prefrontal cortex, and areas V4, IT for attention and eye movement [PDF]
, 2005 Attention is known to play a key role in perception, including action selection, object recognition and memory. Despite findings revealing competitive interactions among cell populations, attention remains difficult to explain.
Hamker, Fred H.
core +4 more sources
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Reinforcement learning based local search for grouping problems: A case study on graph coloring [PDF]
, 2016 Grouping problems aim to partition a set of items into multiple mutually disjoint subsets according to some specific criterion and constraints. Grouping problems cover a large class of important combinatorial optimization problems that are generally ...
Duval, Béatrice +2 more
core +5 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
DIFFERENTIAL EVOLUTION WITH COMPETITIVE SETTING OF CONTROL PARAMETERS
TASK Quarterly, 2007 This paper is focused on the adaptation of control parameters in differential evolution. Competition of various control parameter settings was proposed in order to ensure self-adaptation of parameter values in the search process.
JOSEF TVRD´IK
doaj
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
On local search based heuristics for optimization problems
Croatian Operational Research Review, 2014 When comparing various metaheuristics, even asking a fair and formally consis-tent question is often difficult. Having this in mind, we provide some further evidence that simple local search heuristics may be at least a very competitive choice.
David Kaljun, Janez Žerovnik
doaj +1 more source
Efficient Novelty Search Through Deep Reinforcement Learning
IEEE Access, 2020 Novelty search, which was inspired by the nature that evolves creatures with diversity, has shown great potential in solving reinforcement learning (RL) tasks with sparse and deceptive rewards.
Longxiang Shi +4 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source