Results 51 to 60 of about 317,143 (313)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Perspectives and Distinctive Particularities of Collaborative Networks [PDF]

Revista de Management Comparat International, 2012
Intra and extra organizational collaboration has become an important factor in increasing organizational competitiveness and regional ones. Technical and technological progress and the knowledge economy have led to the emergence of collaborative networks.
Alexandru Ionuţ ROJA, Marian NĂSTASE
doaj  

Competitive Strategies for Corporate Sustainability

Foresight and STI Governance, 2023
This is an exploratory study to gain insight among tax and ESG practitioners on the linkage between ESG and tax compliance. Prior studies used secondary data to examine the association between ESG and tax avoidance and reported inconclusive results ...
Mohd Zulkhairi Mustapha, Zarina Zakaria, Nurliana Md Rahin, Noorsakinah Binti Abdul Wahab   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

A STUDY ON THE COMPETITION STRATEGIES IMPLEMENTED IN THE AIRLINE COMPANIES IN TURKEY

Sosyal Ekonomik Araştırmalar Dergisi, 2009
Bu çalışmanın amacı Türkiye’deki havayolu yolcu taşıma şirketlerinde uygulanan rekabet stratejilerini belirleyerek, bu stratejilerin havacılık sektörü ve havayolu şirketleri üzerindeki etkilerini incelemektir.
İzzet Kılınç, Mehmet Akif Öncü, Yunus Emre Taşgıt   +2 more
doaj   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Thirty Years Later, or The Biological Approach to Competition Revisited

Современная конкуренция
The article discusses the effectiveness of the biological approach of generic strategies of competition by L. G. Ramensky - J. P. Grime to economic processes. Four main strategies are considered: violent, patient, commutant, and explorant.
Andrey Yu. Yudanov
doaj   +1 more source

Estratégias Competitivas para Empresas de Rochas Ornamentais na Região Metropolitana do Rio de Janeiro [PDF]

Anuário do Instituto de Geociências, 2005
The strategy to accelerate the development of mining-beneficiationtechnology- competitivity management of dimension stone companies involves various analysis and alternative methodologies.
Claudio Margueron, Edson Farias Mello
doaj  

Globalização e estratégias competitivas na indústria automobilística: uma abordagem a partir das principais montadoras instaladas no Brasil Globalization and competitive strategies in the automotive industry: an approach from the pespective of the main assemblers in Brazil

Gestão & Produção, 2005
O presente artigo primeiramente trata do processo de globalização da indústria automobilística internacional. Da mesma forma, o importante papel desempenhado pela introdução de novas tecnologias nessa indústria é também considerado.
Enéas Gonçalves de Carvalho
doaj   +1 more source