Results 61 to 70 of about 1,098,013 (297)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Competitiveness And Competitive Strategies
Ciencia y ReflexiónThe business competitiveness is one of the most recurrent study topics in the last century and a matter of great concern in Latin American countries, given the changing conditions of the markets. This article aims to analyze the relationship between the strategic management of organizations and business competitiveness in order to validate the most ...
Benjamin Andres Manjarres Zarate +2 more
openaire +1 more source
Political Competitiveness [PDF]
Political competitiveness – which many interpret as the degree of democracy – can be modeled as a monopolistic competition. All regimes are constrained by the threat of "entry," and thereby seek some combination of popular support and political entry ...
Casey B. Mulligan, Kevin K. Tsui
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Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Dendrometer as a water stress indicator for apple trees
Agricultural Water ManagementThe use of dendrometers to measure the stem diameter (SD) of trees provides information about their actual water stress levels. The Scholander chamber is currently the gold standard for measuring stem water potential and thus for quantifying the water ...
Thainná Waldburger +6 more
doaj +1 more source
(Re)-structuring the Ceo’s compensation—the case of Israel
Economics and Business Review, 2020 The executive compensation issue continues to cause protest due to the increasing number of cases of an unjustifiably high level of pay. The main conflict arises from the misalignment of interests between the short-term expectations of the manager and ...
Mroczek-Dąbrowska Katarzyna +1 more
doaj +1 more source
Assessing competitiveness: how firm-level data can help [PDF]
As policymakers refocus on growth, the ability to take a firm-level view is key to disentangling the various factors at the root of competitiveness, and thus to designing appropriate policies.
Carlo Altomonte +3 more
core +1 more source
How Competitive Are State Insurance Markets? [PDF]
, 2011 Assesses the competitiveness of state health insurance markets for individuals and small groups. Explains how market competitiveness will affect state policy decisions on insurance exchange design, new market rules, and rate ...
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