Results 61 to 70 of about 1,254,653 (348)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Competition of Species with Intra-Specific Competition [PDF]
Mathematical Modelling of Natural Phenomena, 2008 Summary: Intra-specific competition in population dynamics can be described by integro-differential equations where the integral term corresponds to nonlocal consumption of resources by individuals of the same population. Already the single integro-differential equation can show the emergence of nonhomogeneous in space stationary structures and can be ...
Apreutesei, Narcisa +2 more
openaire +3 more sources
Journal of Entrepreneurship, Management and Innovation, 2014 More and more, the ability to innovate can be considered as an explanatory factor in determining the long-term potential of firms to be competitive.
Henar Alcalde Heras
doaj +1 more source
Entrepreneurial Alertness Research: Past and Future
SAGE Open, 2021 The construct of entrepreneurial alertness has been gaining considerable interest from academics because it is at the heart of the entrepreneurial process.
Ana Dias Daniel +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Competitive Science: Is Competition Ruining Science? [PDF]
Infection and Immunity, 2015 ABSTRACTScience has always been a competitive undertaking. Despite recognition of the benefits of cooperation and team science, reduced availability of funding and jobs has made science more competitive than ever. Here we consider the benefits of competition in providing incentives to scientists and the adverse effects of competition on resource ...
Ferric C, Fang, Arturo, Casadevall
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Competitiveness And Competitive Strategies
Ciencia y ReflexiónThe business competitiveness is one of the most recurrent study topics in the last century and a matter of great concern in Latin American countries, given the changing conditions of the markets. This article aims to analyze the relationship between the strategic management of organizations and business competitiveness in order to validate the most ...
Benjamin Andres Manjarres Zarate +2 more
openaire +1 more source
Key role for inhibins in effective T cell activation, migration and Th17 differentiation
FEBS Open Bio, EarlyView.Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco +5 more
wiley +1 more source