Results 51 to 60 of about 1,114,682 (316)

Smooth transition regression model relating inflation to economic growth in Tunisia

Journal of Economic Structures, 2023
Since its independence, Tunisia has embarked on monetary and financial sector reforms aimed at boosting economic growth. However, these reforms have not been effective due to inflation pressures in this country.
Hamdi Becha, Maha Kalai, Kamel Helali
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Challenges for co-generation in the search for social impact of the university: a case of the construction of a dialogic space through action research

European Public & Social Innovation Review, 2018
At the center of the debate about the social impact of the university we find a new division of work in the production of knowledge that can respond to the challenges of society.
Patricia Canto, , Pablo Costamagna, , Andoni Eizagirre, , Miren Larrea   +3 more
doaj   +1 more source

New resonance approach to competitiveness interventions in lagging regions: the case of Ukraine before the armed conflict [PDF]

, 2017
Regional competitiveness is considered to be an alternative basis for the determination of regional interventions. However, the composite competitiveness indicator is quite sensitive to the weights of sub-indicators, no matter what methodology is being ...
Ahner, Ahner, Annoni, Annoni, Annoni, Annoni, Aranguren, Aranguren, Brussel, Brussel, Camagni, Camagni, Camagni, Camagni, Charles, Charles, Charnes, Charnes, Cooke, Cooke, Cооке, Cооке, Fernandez, Fernandez, Flood, Flood, Flood, Flood, Gábor, Gábor, Harmaakorpi, Harmaakorpi, Harman, Harman, Hellwig, Hellwig, Hollanders, Hollanders, Huggins, Huggins, Huggins, Huggins, Hugins, Hugins, Huovari, Huovari, Jackson, Jackson, Kiszová, Kiszová, Kuznets, Kuznets, London, London, Martin, Martin, Martin, Martin, Melecký, Melecký, Meyer, Meyer, Midelfart, Midelfart, Midgley, Midgley, Mingers, Mingers, Myrdal, Myrdal, Nevima, Nevima, Oliva, Oliva, Perroux, Perroux, Pessoa, Pessoa, Pluta, Pluta, Porter, Porter, Puga, Puga, Pооt, Pооt, Ramík, Ramík, Różańska, Różańska, Schaffer, Schaffer, Snieška, Snieška, Storper, Storper, Tetsuya, Tetsuya, UNDP, UNDP   +99 more
core   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Corporate Social Responsibility: Historical Overview and Conceptual Framework

Journal of Environmental Management and Tourism
The emergence of unprecedented socio-environmental challenges has highlighted the need for a profound transformation of traditional business models.
Lamia EL BADRI, Mohammed Rachid AASRI, Meryem HOUMAIR, Anouar FAITEH   +3 more
doaj   +1 more source

A survey-based design of a pricing system for psychotherapy

Health Economics Review, 2018
For admission to statutory health insurance, it is common in Switzerland that health care providers negotiate prices for health care services directly with health insurers. Once they agree upon a price, they must submit the resulting price to the Federal
Beat Hulliger, Martin Sterchi
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source