Results 61 to 70 of about 1,114,682 (316)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Collaboration Patterns and Product Innovation in the Basque Country. Does a Firm’s Nationality Matter?

Journal of Entrepreneurship, Management and Innovation, 2014
More and more, the ability to innovate can be considered as an explanatory factor in determining the long-term potential of firms to be competitive.
Henar Alcalde Heras
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Analysis of Economic and Growth Synchronization Between China and the USA Using a Markov-Switching–VAR Model: A Trend and Cycle Approach

Computer Sciences & Mathematics Forum
This study examines the synchronization of economic and growth cycles between China and the United States of America amid ongoing economic and geopolitical tensions.
Mariem Bouattour, Malek Abaab, Hajer Chibani, Hamdi Becha, Kamel Helali   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Competitiveness And Competitive Strategies

Ciencia y Reflexión
The business competitiveness is one of the most recurrent study topics in the last century and a matter of great concern in Latin American countries, given the changing conditions of the markets. This article aims to analyze the relationship between the strategic management of organizations and business competitiveness in order to validate the most ...
Benjamin Andres Manjarres Zarate, Wilson Ricardo Pinillos Castillo, Diego Hernán Valbuena Montoya   +2 more
openaire   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Dendrometer as a water stress indicator for apple trees

Agricultural Water Management
The use of dendrometers to measure the stem diameter (SD) of trees provides information about their actual water stress levels. The Scholander chamber is currently the gold standard for measuring stem water potential and thus for quantifying the water ...
Thainná Waldburger, Achim Walter, Marianne Cockburn, Hassan-Roland Nasser, Philippe Monney, Matthias Hatt, Thomas Anken   +6 more
doaj   +1 more source

Identifying Opportunities to Improve Competitiveness through Innovation Illustrated on the Example of Hungary [PDF]

, 2013
Due to the economic downturn there is an increased need for companies and economies to outperform their competitors and gain sustainable competitive adventage. However, competiveness is a complex concept.
Bene, Andrea, Szabó, Virág, Óhegyi, Katalin   +2 more
core   +1 more source